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A fieldable electro...
A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols
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- de Sousa, Nuno Rufino (författare)
- Karolinska Institutet
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- Sandström, Niklas, 1981- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
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- Shen, Lei (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden.;Tongji Univ, Shanghai Pulm Hosp, Sch Med, Shanghai, Peoples R China.
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- Håkansson, Kathleen (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden.
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- Vezozzo, Rafaella (författare)
- Fed Univ Grande Dourados, Fac Hlth Sci, Dourados, MS, Brazil.
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- Udekwu, Klas (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.;SoS BIOS, Uppsala, Sweden.
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- Croda, Julio (författare)
- Univ Fed Mato Grosso do Sul, Sch Med, Campo Grande, MS, Brazil.;Fundacao Oswaldo Cruz, Campo Grande, MS, Brazil.
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- Gigliotti Rothfuchs, Antonio (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Tuberculosis. - : Elsevier BV. - 1472-9792 .- 1873-281X. ; 120
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Tuberculosis (TB) infects about 25% of the world population and claims more human lives than any other infectious disease. TB is spread by inhalation of aerosols containing viable Mycobacterium tuberculosis expectorated or exhaled by patients with active pulmonary disease. Air-sampling technology could play an important role in TB control by enabling the detection of airborne M. tuberculosis, but tools that are easy to use and scalable in TB hotspots are lacking. We developed an electrostatic air sampler termed the TB Hotspot DetectOR (THOR) and investigated its performance in laboratory aerosol experiments and in a prison hotspot of TB transmission. We show that THOR collects aerosols carrying microspheres, Bacillus globigii spores and M. bovis BCG, concentrating these microparticles onto a collector piece designed for subsequent detection analysis. The unit was also successfully operated in the complex setting of a prison hotspot, enabling detection of a molecular signature for M. tuberculosis in the cough of inmates. Future deployment of this device may lead to a measurable impact on TB case-finding by screening individuals through the aerosols they generate.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- Tuberculosis
- Bioaerosols
- Air sampling
- Pathogen detection
- Diagnostics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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