Peak expiratory flow, walking speed and survival in older adults: An 18-year longitudinal population-based study

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Trevisan, CaterinaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Padova, Italy (author)

Peak expiratory flow, walking speed and survival in older adults : An 18-year longitudinal population-based study

Article/chapterEnglish2020

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Elsevier BV,2020
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LIBRIS-ID:oai:DiVA.org:su-182826
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-182826URI
https://doi.org/10.1016/j.exger.2020.110941DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:143689539URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background: Peak expiratory flow (PEF) and walking speed (WS) have been proposed as indicators of robustness and are independent predictors of health-related outcomes. We aimed to investigate how the co-occurrence of respiratory and physical impairments changes as a function of age, and to quantify the association of the combination of low PEF and slow WS on survival in older people.Methods: This prospective study analyzes data from 2656 community-dwelling participants (age >= 60 years) from the SNAC-K study. At baseline, we assessed: (1) sociodemographic, lifestyle and medical data; (2) respiratory function, estimated through PEF and expressed as standardized residual (SR) percentile; and (3) WS at usual pace, categorized as no (> 1.2 m/s), mild (0.8-1.2 m/s) and moderate-to-severe (< 0.8 m/s) walking impairment. Participants' vital status over an 18-year follow-up was derived from registers. The association of different combinations of PEF and WS on median survival time was estimated through Laplace regression adjusted for potential confounders.Results: Respiratory and walking impairments co-occurred more frequently with increasing age. Among individuals with PEF SR-percentiles < 10th, the percentage of moderate-to-severe walking impairment was 12.1% in sexagenarians, 35.7% in septuagenarians, and 75-80% in the oldest old. The greatest reduction in median survival time (- 5.4 [95%CI: -6.4; -4.4] years, p < 0.001) was observed among people with combined respiratory and moderate-to-severe walking impairments, compared with those with no dysfunctions, who had a median survival time of 17.4 (95%CI: 17.0; 17.8) years.Conclusions: Impaired PEF and WS co-occur more frequently with advancing age, and their co-occurrence is associated with shorter survival.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
Respiratory function
Walking speed
Survival
Aging

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Rizzuto, DeboraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden (author)
Sergi, Giuseppe (author)
Maggi, Stefania (author)
Welmer, Anna-KarinKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden; Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden (author)
Vetrano, Davide L.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),IRCCS Fondazione Policlinico “A. Gemelli”, Italy; Catholic University of Rome, Italy (author)
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

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