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Balance between Tra...
Balance between Transmitter Availability and Dopamine D2 Receptors in Prefrontal Cortex Influences Memory Functioning
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- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Salami, Alireza (author)
- Karolinska Institutet,Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Rieckmann, Anna (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Andersson, Micael (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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Lindenberger, Ulman (author)
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- Lövdén, Martin (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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(creator_code:org_t)
- 2019-09-02
- 2020
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 30:3, s. 989-1000
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Insufficient or excessive dopaminergic tone impairs cognitive performance. We examine whether the balance between transmitter availability and dopamine (DA) D2 receptors (D2DRs) is important for successful memory performance in a large sample of adults (n= 175, 64-68 years). The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [C-11]raclopride-PET. Individuals for whom D2DR status matched DA availability showed higher levels of episodic and working-memory performance than individuals with insufficient or excessive DA availability relative to the number of receptors. A similar pattern restricted to episodic memory was observed for D2DRs in caudate. Functional magnetic resonance imaging data acquired during working-memory performance confirmed the importance of a balanced DA system for load-dependent brain activity in dlPFC. Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- [C-11] raclopride
- catechol-O-methyltransferase
- dopamine D2 receptors
- episodic memory
- working memory
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Papenberg, Goran
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Karalija, Nina, ...
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Salami, Alireza
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Rieckmann, Anna
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Andersson, Micae ...
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Axelsson, Jan, 1 ...
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Riklund, Katrine ...
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Lindenberger, Ul ...
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Lövdén, Martin
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Nyberg, Lars, 19 ...
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Bäckman, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cerebral Cortex
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet