Sökning: onr:"swepub:oai:DiVA.org:su-184480" > A Patient-Derived C...
Fältnamn | Indikatorer | Metadata |
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000 | 07153naa a2200841 4500 | |
001 | oai:DiVA.org:su-184480 | |
003 | SwePub | |
008 | 200918s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:144202556 | |
009 | oai:DiVA.org:uu-419794 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1844802 URI |
024 | 7 | a https://doi.org/10.1016/j.celrep.2020.1078972 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442025562 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4197942 URI |
040 | a (SwePub)sud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Johansson, Patriku Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)patjo183 |
245 | 1 0 | a A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma |
264 | 1 | b Elsevier BV,c 2020 |
338 | a print2 rdacarrier | |
500 | a Patrik Johansson, Cecilia Krona and Soumi Kundu share first authorship | |
520 | a Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually exclusive aberrations in TP53 and CDKN2A/B. We confirm this trend in cell and in xenotransplantation models, and identify both Bcl-2 family inhibitors and p53 activators as potentiators of proteasome inhibitors in GBM cells, We can further predict the responses of individual cell cultures to several existing drug classes, presenting opportunities for drug repurposing and design of stratified trials. Our functionally profiled biobank provides a valuable resource for the discovery of new treatments for GBM. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a biobank | |
653 | a combination therapy | |
653 | a data integration | |
653 | a glioblastoma | |
653 | a multi-omics | |
653 | a p53 reactivators | |
653 | a patient-derived cells | |
653 | a primary cells | |
653 | a proteasome | |
700 | 1 | a Krona, Cecilia,d 1976-u Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ceckr429 |
700 | 1 | a Kundu, Soumiu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi4 aut0 (Swepub:uu)suoku676 |
700 | 1 | a Doroszko, Milenau Uppsala universitet,Neuroonkologi4 aut0 (Swepub:uu)mildo141 |
700 | 1 | a Baskaran, Sathishkumaru Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)satsa338 |
700 | 1 | a Schmidt, Linneau Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)linsc345 |
700 | 1 | a Vinel, Claireu Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2AT, England.4 aut |
700 | 1 | a Almstedt, Elin,d 1988-u Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)elial205 |
700 | 1 | a Elgendy, Ramyu Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ramel266 |
700 | 1 | a Elfineh, Lioudmilau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi4 aut0 (Swepub:uu)liouelfi |
700 | 1 | a Gallant, Caroline J.u Uppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)carga920 |
700 | 1 | a Lundsten, Sarau Uppsala universitet,Medicinsk strålningsvetenskap,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarlu248 |
700 | 1 | a Ferrer Gago, Fernando J.u Agcy Sci Technol & Res Star, Singapore 138648, Singapore.4 aut |
700 | 1 | a Hakkarainen, Aleksiu Univ Turku, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku 20500, Finland.4 aut |
700 | 1 | a Sipila, Petrau Univ Turku, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku 20500, Finland.4 aut |
700 | 1 | a Häggblad, Mariau Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, SciLifeLab, S-10405 Stockholm, Sweden.4 aut0 (Swepub:su)maha7002 |
700 | 1 | a Martens, Ulfu Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, SciLifeLab, S-10405 Stockholm, Sweden.4 aut0 (Swepub:su)ulma3535 |
700 | 1 | a Lundgren, Bou Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, SciLifeLab, S-10405 Stockholm, Sweden.4 aut0 (Swepub:su)bolu7255 |
700 | 1 | a Frigault, Melanie M.u AstraZeneca Oncol, Waltham, MA 02451 USA.4 aut |
700 | 1 | a Lane, David P.u Agcy Sci Technol & Res Star, Singapore 138648, Singapore.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Sci Life Lab, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Swartling, Fredrik J,d 1975-u Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fredjoha |
700 | 1 | a Uhrbom, Leneu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi4 aut0 (Swepub:uu)leneuhrb |
700 | 1 | a Nestor, Marika,d 1976-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk strålningsvetenskap4 aut0 (Swepub:uu)manes424 |
700 | 1 | a Marino, Silviau Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2AT, England.4 aut |
700 | 1 | a Nelander, Svenu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi4 aut0 (Swepub:uu)svene843 |
710 | 2 | a Uppsala universitetb Neuroonkologi4 org |
773 | 0 | t Cell Reportsd : Elsevier BVg 32:2q 32:2x 2211-1247 |
856 | 4 | u https://doi.org/10.1016/j.celrep.2020.107897y Fulltext |
856 | 4 | u http://www.cell.com/article/S2211124720308780/pdf |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1467922/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-184480 |
856 | 4 8 | u https://doi.org/10.1016/j.celrep.2020.107897 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144202556 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419794 |
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