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  • Cousins, Ian T.Stockholms universitet,Institutionen för miljövetenskap (author)

Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020
  • Royal Society of Chemistry (RSC),2020
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:su-184547
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-184547URI
  • https://doi.org/10.1039/d0em00147cDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Grouping strategies are needed for per- and polyfluoroalkyl substances (PFAS), in part, because it would be time and resource intensive to test and evaluate the more than 4700 PFAS on the global market on a chemical-by-chemical basis. In this paper we review various grouping strategies that could be used to inform actions on these chemicals and outline the motivations, advantages and disadvantages for each. Grouping strategies are subdivided into (1) those based on the intrinsic properties of the PFAS (e.g.persistence, bioaccumulation potential, toxicity, mobility, molecular size) and (2) those that inform risk assessment through estimation of cumulative exposure and/or effects. The most precautionary grouping approach of those reviewed within this article suggests phasing out PFAS based on their high persistence alone (the so-called P-sufficient approach). The least precautionary grouping approach reviewed advocates only grouping PFAS for risk assessment that have the same toxicological effects, modes and mechanisms of action, and elimination kinetics, which would need to be well documented across different PFAS. It is recognised that, given jurisdictional differences in chemical assessment philosophies and methodologies, no one strategy will be generally acceptable. The guiding question we apply to the reviewed grouping strategies is: grouping for what purpose? The motivation behind the grouping (e.g.determining use in productsvs.setting guideline levels for contaminated environments) may lead to different grouping decisions. This assessment provides the necessary context for grouping strategies such that they can be adopted as they are, or built on further, to protect human and environmental health from potential PFAS-related effects.

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  • DeWitt, Jamie C. (author)
  • Glüge, Juliane (author)
  • Goldenman, Gretta (author)
  • Herzke, Dorte (author)
  • Lohmann, Rainer (author)
  • Miller, Mark (author)
  • Ng, Carla A. (author)
  • Scheringer, Martin (author)
  • Vierke, Lena (author)
  • Wang, Zhanyun (author)
  • Stockholms universitetInstitutionen för miljövetenskap (creator_code:org_t)

Related titles

  • In:Environmental Science: Royal Society of Chemistry (RSC)22:7, s. 1444-14602050-78872050-7895

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