Sökning: WFRF:(Teichmann Sarah A.)
> (2020-2022) >
Mosquito cellular i...
Mosquito cellular immunity at single-cell resolution
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Raddi, Gianmarco (författare)
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Barletta, Ana Beatriz F. (författare)
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Efremova, Mirjana (författare)
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Ramirez, Jose Luis (författare)
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- Cantera, Rafael, 1953- (författare)
- Stockholms universitet,Zoologiska institutionen,Instituto de Investigaciones Biológicas Clemente Estable, Uruguay
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Teichmann, Sarah A. (författare)
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Barillas-Mury, Carolina (författare)
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- Billker, Oliver (författare)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Wellcome Sanger Institute, Hinxton, Cambridge CB10 2AZ, UK
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2020
- 2020
- Engelska.
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 369:6507, s. 1128-1132
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Hemocytes limit the capacity of mosquitoes to transmit human pathogens. Here we profile the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquito vectors. Our data reveal the functional diversity of hemocytes, with different subtypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes. A previously unidentified cell type in An. gambiae, which we term “megacyte,” is defined by a specific transmembrane protein marker (TM7318) and high expression of lipopolysaccharide-induced tumor necrosis factor–α transcription factor 3 (LL3). Knockdown experiments indicate that LL3 mediates hemocyte differentiation during immune priming. We identify and validate two main hemocyte lineages and find evidence of proliferating granulocyte populations. This atlas of medically relevant invertebrate immune cells at single-cell resolution identifies cellular events that underpin mosquito immunity to malaria infection.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- genetik
- Genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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