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ARG1-expressing mic...
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
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- Stratoulias, Vassilis (författare)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland
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- Ruiz, Rocío (författare)
- Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
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- Kanatani, Shigeaki (författare)
- Karolinska Institutet
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- Osman, Ahmed M. (författare)
- Karolinska Institutet
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- Keane, Lily (författare)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Armengol, Jose A. (författare)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Rodríguez-Moreno, Antonio (författare)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Murgoci, Adriana-Natalia (författare)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- García-Domínguez, Irene (författare)
- Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
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- Alonso-Bellido, Isabel (författare)
- Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
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- González Ibáñez, Fernando (författare)
- Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
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- Picard, Katherine (författare)
- Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
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- Vázquez-Cabrera, Guillermo (författare)
- Karolinska Institutet
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- Posada-Pérez, Mercedes (författare)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
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- Vernoux, Nathalie (författare)
- Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada
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- Tejera, Dario (författare)
- Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany
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- Grabert, Kathleen (författare)
- Karolinska Institutet
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- Cheray, Mathilde (författare)
- Karolinska Institutet
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- González-Rodríguez, Patricia (författare)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Pérez-Villegas, Eva M. (författare)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Martínez-Gallego, Irene (författare)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Lastra-Romero, Alejandro (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Brodin, David (författare)
- Karolinska Institutet
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- Avila-Cariño, Javier, 1957- (författare)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Cao, Yang, Associate Professor, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Airavaara, Mikko (författare)
- Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland; Faculty of Pharmacy, Drug Research Program, University of Helsinki, Helsinki, Finland
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- Uhlén, Per (författare)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Heneka, Michael T. (författare)
- Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, MA, Worcester, United States
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- Tremblay, Marie-Ève (författare)
- Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
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- Blomgren, Klas (författare)
- Karolinska Institutet
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- Venero, Jose L. (författare)
- Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
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- Joseph, Bertrand (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Nature Publishing Group, 2023
- 2023
- Engelska.
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Ingår i: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 26:6, s. 1008-1020
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+ microglia) that is found predominantly in the basal forebrain and ventral striatum during early postnatal mouse development. ARG1+ microglia are enriched in phagocytic inclusions and exhibit a distinct molecular signature, including upregulation of genes such as Apoe, Clec7a, Igf1, Lgals3 and Mgl2, compared to ARG1- microglia. Microglial-specific knockdown of Arg1 results in deficient cholinergic innervation and impaired dendritic spine maturation in the hippocampus where cholinergic neurons project, which in turn results in impaired long-term potentiation and cognitive behavioral deficiencies in female mice. Our results expand on microglia diversity and provide insights into microglia subtype-specific functions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Stratoulias, Vas ...
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Ruiz, Rocío
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Kanatani, Shigea ...
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Osman, Ahmed M.
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Keane, Lily
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Armengol, Jose A ...
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visa fler...
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Rodríguez-Moreno ...
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Murgoci, Adriana ...
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García-Domínguez ...
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Alonso-Bellido, ...
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González Ibáñez, ...
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Picard, Katherin ...
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Vázquez-Cabrera, ...
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Posada-Pérez, Me ...
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Vernoux, Nathali ...
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Tejera, Dario
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Grabert, Kathlee ...
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Cheray, Mathilde
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González-Rodrígu ...
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Pérez-Villegas, ...
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Martínez-Gallego ...
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Lastra-Romero, A ...
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Brodin, David
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Avila-Cariño, Ja ...
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Cao, Yang, Assoc ...
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Airavaara, Mikko
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Uhlén, Per
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Heneka, Michael ...
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Tremblay, Marie- ...
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Blomgren, Klas
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Venero, Jose L.
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Joseph, Bertrand
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Nature Neuroscie ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet