More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

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More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

Parma, Valentina (author)

Ohla, Kathrin (author)

Veldhuizen, Maria G. (author)

Niv, Masha Y. (author)

Kelly, Christine E. (author)

Bakke, Alyssa J. (author)

Cooper, Keiland W. (author)

Bouysset, Cédric (author)

Pirastu, Nicola (author)

Dibattista, Michele (author)

Kaur, Rishemjit (author)

Liuzza, Marco Tullio (author)

Pepino, Marta Y. (author)

Schöpf, Veronika (author)

Pereda-Loth, Veronica (author)

Olsson, Shannon B. (author)

Gerkin, Richard C. (author)

Dominguez, Paloma Rohlfs (author)

Albayay, Javier (author)

Farruggia, Michael C. (author)

Bhutani, Surabhi (author)

Fjaeldstad, Alexander W. (author)

Kumar, Ritesh (author)

Menini, Anna (author)

Bensafi, Moustafa (author)

Sandell, Mari (author)

Konstantinidis, Iordanis (author)

Di Pizio, Antonella (author)

Genovese, Federica (author)

Öztürk, Lina (author)

Thomas-Danguin, Thierry (author)

Frasnelli, Johannes (author)

Boesveldt, Sanne (author)

Saatci, Özlem (author)

Saraiva, Luis R. (author)

Lin, Cailu (author)

Golebiowski, Jérôme (author)

Hwang, Liang-Dar (author)

Ozdener, Mehmet Hakan (author)

Guàrdia, Maria Dolors (author)

Laudamiel, Christophe (author)

Ritchie, Marina (author)

Havlícek, Jan (author)

Pierron, Denis (author)

Roura, Eugeni (author)

Navarro, Marta (author)

Nolden, Alissa A. (author)

Lim, Juyun (author)

Whitcroft, Katherine L. (author)

Colquitt, Lauren R. (author)

Ferdenzi, Camille (author)

Brindha, Evelyn (author)

Altundag, Aytug (author)

Macchi, Alberto (author)

Nunez-Parra, Alexia (author)

Patel, Zara M. (author)

Fiorucci, Sébastien (author)

Philpott, Carl M. (author)

Smith, Barry C. (author)

Lundström, Johan N. (author): Karolinska Institutet

Mucignat, Carla (author)

Parker, Jane K. (author)

van den Brink, Mirjam (author)

Schmuker, Michael (author)

Fischmeister, Florian Ph S. (author)

Heinbockel, Thomas (author)

Shields, Vonnie D. C. (author)

Faraji, Farhoud (author)

Santamaria, Enrique (author)

Fredborg, William E. A. (author): Stockholms universitet,Psykologiska institutionen

Morini, Gabriella (author)

Olofsson, Jonas K. (author): Stockholms universitet,Psykologiska institutionen

Jalessi, Maryam (author)

Karni, Noam (author)

D'Errico, Anna (author)

Alizadeh, Rafieh (author)

Pellegrino, Robert (author)

Meyer, Pablo (author)

Huart, Caroline (author)

Chen, Ben (author)

Soler, Graciela M. (author)

Alwashahi, Mohammed K. (author)

Welge-Lüssen, Antje (author)

Freiherr, Jessica (author)

de Groot, Jasper H. B. (author)

Klein, Hadar (author)

Okamoto, Masako (author)

Singh, Preet Bano (author)

Hsieh, Julien W. (author)

Reed, Danielle R. (author)

Hummel, Thomas (author)

Munger, Steven D. (author)

Hayes, John E. (author)

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(creator_code:org_t)

2020-06-20
2020
English.
In: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 45:7, s. 609-622

Related links:: https://doi.org/10.1...; show more...; https://academic.oup...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19–79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

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By the author/editor: Parma, Valentina; Ohla, Kathrin; Veldhuizen, Mari ...; Niv, Masha Y.; Kelly, Christine ...; Bakke, Alyssa J.; show more...; Cooper, Keiland ...; Bouysset, Cédric; Pirastu, Nicola; Dibattista, Mich ...; Kaur, Rishemjit; Liuzza, Marco Tu ...; Pepino, Marta Y.; Schöpf, Veronika; Pereda-Loth, Ver ...; Olsson, Shannon ...; Gerkin, Richard ...; Dominguez, Palom ...; Albayay, Javier; Farruggia, Micha ...; Bhutani, Surabhi; Fjaeldstad, Alex ...; Kumar, Ritesh; Menini, Anna; Bensafi, Moustaf ...; Sandell, Mari; Konstantinidis, ...; Di Pizio, Antone ...; Genovese, Federi ...; Öztürk, Lina; Thomas-Danguin, ...; Frasnelli, Johan ...; Boesveldt, Sanne; Saatci, Özlem; Saraiva, Luis R.; Lin, Cailu; Golebiowski, Jér ...; Hwang, Liang-Dar; Ozdener, Mehmet ...; Guàrdia, Maria D ...; Laudamiel, Chris ...; Ritchie, Marina; Havlícek, Jan; Pierron, Denis; Roura, Eugeni; Navarro, Marta; Nolden, Alissa A ...; Lim, Juyun; Whitcroft, Kathe ...; Colquitt, Lauren ...; Ferdenzi, Camill ...; Brindha, Evelyn; Altundag, Aytug; Macchi, Alberto; Nunez-Parra, Ale ...; Patel, Zara M.; Fiorucci, Sébast ...; Philpott, Carl M ...; Smith, Barry C.; Lundström, Johan ...; Mucignat, Carla; Parker, Jane K.; van den Brink, M ...; Schmuker, Michae ...; Fischmeister, Fl ...; Heinbockel, Thom ...; Shields, Vonnie ...; Faraji, Farhoud; Santamaria, Enri ...; Fredborg, Willia ...; Morini, Gabriell ...; Olofsson, Jonas ...; Jalessi, Maryam; Karni, Noam; D'Errico, Anna; Alizadeh, Rafieh; Pellegrino, Robe ...; Meyer, Pablo; Huart, Caroline; Chen, Ben; Soler, Graciela ...; Alwashahi, Moham ...; Welge-Lüssen, An ...; Freiherr, Jessic ...; de Groot, Jasper ...; Klein, Hadar; Okamoto, Masako; Singh, Preet Ban ...; Hsieh, Julien W.; Reed, Danielle R ...; Hummel, Thomas; Munger, Steven D ...; Hayes, John E.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Otorhinolaryngol ...

Articles in the publication: Chemical Senses

By the university: Stockholm University; Karolinska Institutet

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More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

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