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Exercise testing fo...
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Husser, Oliver
(författare)
Exercise testing for non-invasive assessment of atrial electrophysiological properties in patients with persistent atrial fibrillation
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-06-26
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Oxford University Press (OUP),2007
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:6050a958-93f8-4b02-8dc3-3d6e67087e9d
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https://lup.lub.lu.se/record/655731URI
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https://doi.org/10.1093/europace/eum124DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Aims Experimental studies suggest that the autonomic nervous system modulates atrial refractoriness and conduction velocity in atrial. fibrillation (AF). These modulatory effects are, however, difficult to assess in the clinical setting. This study sought to non-invasively characterize in patients with persistent AF, the influence of autonomic modulation induced by exercise on atrial fibrillatory rate as marker of atrial refractoriness and to identify clinical and electrocardiographic predictors of atrial rate response. Methods and results In 24 patients (16 mates, mean age 60 +/- 13 years) with persistent AF (16 +/- 25 months), continuous ECGs were recorded during bicycle exercise testing. Fibrillatory rate (in fibrillations per minute, fpm) was assessed at baseline and immediately after termination of exercise with spatiotemporal QRST cancellation and time-frequency analysis. Ventricular response was characterized by time-domain HRV indices. Exercise had no influence on mean fibrillatory rate (409 +/- 42 vs. 414 +/- 43 fpm, P = NS). Seven patients responded to exercise with an increase in fibrillatory rate (26 10 fpm, P < 0.001 and three with a decrease (-21 +/- 8 fpm, P < 0.001), while the remaining 14 patients did not show a response. Responders' HRV indices changed in response to exercise similarly to that of non-responders. Their baseline fibrillatory rate was, however, lower than that of non-responders (387 +/- 18 vs. 425 +/- 48 fpm, P = 0.028). No other clinical or echocardiographic variable was associated with fibrillatory rate response. Twelve weeks after cardioverson, responders were more likely to remain in sinus rhythm than non-responders (88 vs. 46 %, P = 0.04). Conclusions Exercise-induced autonomic activation produces changes in atrial. etectrophysiological properties that can be detected by time-frequency analysis. Higher baseline fibrillatory rates are associated with an impaired atrial response to exercise that suggests advanced electrical remodelling and reduced sensitivity to autonomic stimuli.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Husser, Daniela
(författare)
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Stridh, MartinLund University,Lunds universitet,Institutionen för elektro- och informationsteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Electrical and Information Technology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)tde-mst
(författare)
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Sörnmo, LeifLund University,Lunds universitet,Institutionen för elektro- och informationsteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Electrical and Information Technology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)tde-lso
(författare)
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Corino, Valentina D. A.
(författare)
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Mainardi, Luca T.
(författare)
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Lombardi, Federico
(författare)
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Klein, Helmut U.
(författare)
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Olsson, BertilLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kard-bol
(författare)
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Bollmann, AndreasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kard-abo
(författare)
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Institutionen för elektro- och informationsteknikInstitutioner vid LTH
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Europace: Oxford University Press (OUP)9:8, s. 627-6321532-2092
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Ingår i:EP Europace: Oxford University Press (OUP)9:8, s. 627-6321099-5129
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Husser, Oliver
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Husser, Daniela
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Stridh, Martin
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Sörnmo, Leif
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Corino, Valentin ...
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Mainardi, Luca T ...
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Lombardi, Federi ...
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Klein, Helmut U.
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Olsson, Bertil
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Bollmann, Andrea ...
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Europace
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