Sökning: WFRF:(Hoffman Eric A.) >
A Longitudinal, Int...
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Nader, Gustavo A.Karolinska Institutet
(författare)
A Longitudinal, Integrated, Clinical, Histological and mRNA Profiling Study of Resistance Exercise in Myositis
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-11-01
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Springer Science and Business Media LLC,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-135328
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135328URI
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https://doi.org/10.2119/molmed.2010.00016DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121587419URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Polymyositis and dermatomyositis are orphan, chronic skeletal muscle disorders characterized by weakness, infiltrations by mononuclear inflammatory cells, and fibrosis. Until recently, patients were advised to refrain from physical activity because of fears of exacerbation of muscle inflammation. However, recent studies have shown that moderate exercise training in combination with immunosuppressive drugs can improve muscle performance. Despite the positive effects of exercise training, the molecular mechanisms underlying the exercise-associated clinical improvements remain poorly understood. The present study was designed to define, at the molecular level, the effects of resistance exercise training on muscle performance and disease progression in myositis patients. We evaluated changes in muscle strength, histology and genome-wide mRNA profiles to determine the beneficial effects of exercise and determine the possible molecular changes associated with improved muscle performance. A total of 8 myositis patients underwent a 7-wk resistance exercise training program that resulted in improved muscle strength and increased maximal oxygen uptake (VO2max). Training also resulted in marked reductions in gene expression, reflecting reductions in proinflammatory and profibrotic gene networks, changes that were also accompanied by a reduction in tissue fibrosis. Consistent with the exercise-associated increase in VO2max, a subset of transcripts was associated with a shift toward oxidative metabolism. The changes in gene expression reported in the present study are in agreement with the performance improvements induced by exercise and suggest that resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dastmalchi, Maryam
(författare)
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Alexanderson, HeleneKarolinska Institutet
(författare)
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Grundtman, CeciliaKarolinska Institutet
(författare)
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Gernapudi, Ramkishore
(författare)
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Esbjornsson, MonaKarolinska Institutet
(författare)
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Wang, Zuyi
(författare)
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Rönnelid, JohanUppsala universitet,Enheten för klinisk immunologi(Swepub:uu)joharonn
(författare)
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Hoffman, Eric P.
(författare)
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Nagaraju, Kanneboyina
(författare)
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Lundberg, Ingrid E.Karolinska Institutet
(författare)
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Karolinska InstitutetEnheten för klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Medicine: Springer Science and Business Media LLC16:11-12, s. 455-4641076-15511528-3658
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Nader, Gustavo A ...
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Dastmalchi, Mary ...
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Alexanderson, He ...
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Grundtman, Cecil ...
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Gernapudi, Ramki ...
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Esbjornsson, Mon ...
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Wang, Zuyi
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Rönnelid, Johan
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Hoffman, Eric P.
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Lundberg, Ingrid ...
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Molecular Medici ...
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Uppsala universitet
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Karolinska Institutet