Sökning: L773:1420 3049 OR L773:1420 3049 >
Synthesis of New Na...
Synthesis of New Naphthyl Aceto Hydrazone-Based Metal Complexes : Micellar Interactions, DNA Binding, Antimicrobial, and Cancer Inhibition Studies
-
Ahmad, Fawad (författare)
-
Alkahtani, Muneera D. F. (författare)
-
Taj, Muhammad Babar (författare)
-
visa fler...
-
Alnajeebi, Afnan M. (författare)
-
Alzahrani, Seraj Omar (författare)
-
Babteen, Nouf Abubakr (författare)
-
Alelwani, Walla (författare)
-
Bannunah, Azzah M. (författare)
-
Noor, Sadia (författare)
-
- Ayub, Rabia (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
Tirmizi, Syed Ahmad (författare)
-
Alshater, Heba (författare)
-
visa färre...
-
(creator_code:org_t)
- 2021-02-17
- 2021
- Engelska.
-
Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 26:4
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- In the present study, naphthyl acetohydrazide (HL) ligand was prepared and used for the synthesis of new six amorphous transition metal (Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cd(II)) complexes. All the compounds were characterized by elemental analysis, UV-vis, FT-IR, 1H- and 13C-NMR, and Matrix-Assisted Laser Desorption Ionization (MALDI). The solubilization study was carried out by estimating the interaction between the metal complexes with surfactants viz. sodium stearate (SS) and Cetyltrimethylammonium bromide (CTAB). UV-Visible spectroscopy was employed to determine partitioning and binding parameters, whereas electrical conductivity measurements were employed to estimate critical micellar concentration (CMC), the extent of dissociation, and free energy of micellization. The CT-DNA interaction of synthesized compounds with DNA represents the major groove binding. The synthesized ligand and metal complexes were also tested against bacterial and fungal strains and it has been observed that Cu(II) complex is active against all the strains except Candida albicans, while Cd(II) complex is active against all bacterial and fungal strains except Pseudomonas. Among all compounds, only the Pd(II) complex shows reasonable activity against cervical cancer HeLa cell lines, representing 97% inhibition.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- hydrazones
- DNA interaction
- MALDI
- micellar interaction
- microbial inhibition
- anti-cancer activity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ahmad, Fawad
-
Alkahtani, Munee ...
-
Taj, Muhammad Ba ...
-
Alnajeebi, Afnan ...
-
Alzahrani, Seraj ...
-
Babteen, Nouf Ab ...
-
visa fler...
-
Alelwani, Walla
-
Bannunah, Azzah ...
-
Noor, Sadia
-
Ayub, Rabia
-
Tirmizi, Syed Ah ...
-
Alshater, Heba
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
- Artiklar i publikationen
-
Molecules
- Av lärosätet
-
Stockholms universitet