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Synthesis of New Na...
Synthesis of New Naphthyl Aceto Hydrazone-Based Metal Complexes : Micellar Interactions, DNA Binding, Antimicrobial, and Cancer Inhibition Studies
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Ahmad, Fawad (author)
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Alkahtani, Muneera D. F. (author)
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Taj, Muhammad Babar (author)
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Alnajeebi, Afnan M. (author)
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Alzahrani, Seraj Omar (author)
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Babteen, Nouf Abubakr (author)
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Alelwani, Walla (author)
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Bannunah, Azzah M. (author)
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Noor, Sadia (author)
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- Ayub, Rabia (author)
- Stockholms universitet,Institutionen för organisk kemi
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Tirmizi, Syed Ahmad (author)
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Alshater, Heba (author)
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(creator_code:org_t)
- 2021-02-17
- 2021
- English.
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In: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 26:4
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https://doi.org/10.3...
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https://www.mdpi.com...
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Abstract
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- In the present study, naphthyl acetohydrazide (HL) ligand was prepared and used for the synthesis of new six amorphous transition metal (Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cd(II)) complexes. All the compounds were characterized by elemental analysis, UV-vis, FT-IR, 1H- and 13C-NMR, and Matrix-Assisted Laser Desorption Ionization (MALDI). The solubilization study was carried out by estimating the interaction between the metal complexes with surfactants viz. sodium stearate (SS) and Cetyltrimethylammonium bromide (CTAB). UV-Visible spectroscopy was employed to determine partitioning and binding parameters, whereas electrical conductivity measurements were employed to estimate critical micellar concentration (CMC), the extent of dissociation, and free energy of micellization. The CT-DNA interaction of synthesized compounds with DNA represents the major groove binding. The synthesized ligand and metal complexes were also tested against bacterial and fungal strains and it has been observed that Cu(II) complex is active against all the strains except Candida albicans, while Cd(II) complex is active against all bacterial and fungal strains except Pseudomonas. Among all compounds, only the Pd(II) complex shows reasonable activity against cervical cancer HeLa cell lines, representing 97% inhibition.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- hydrazones
- DNA interaction
- MALDI
- micellar interaction
- microbial inhibition
- anti-cancer activity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahmad, Fawad
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Alkahtani, Munee ...
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Taj, Muhammad Ba ...
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Alnajeebi, Afnan ...
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Alzahrani, Seraj ...
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Babteen, Nouf Ab ...
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show more...
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Alelwani, Walla
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Bannunah, Azzah ...
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Noor, Sadia
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Ayub, Rabia
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Tirmizi, Syed Ah ...
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Alshater, Heba
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Molecules
- By the university
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Stockholm University