Parietal cortex activation predicts longitudinal memory decline in APOE ε4 carriers.

Apolipoprotein E-epsilon 4 is the main known genetic risk factor for Alzheimer’s disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer’s disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at- risk persons. We studied nondemented apolipo-protein E-epsilon 4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon 4 carriers, and hence likely progression to Alzheimer’s disease.

Ingvar, M. (författare)
Persson, J. (författare)
Cruts, M. (författare)
Nilsson, Lars-GöranStockholms universitet,Psykologiska institutionen(Swepub:su)lgn (författare)
Stockholms universitetPsykologiska institutionen (creator_code:org_t)

Av författaren/redakt...: Lind, J.; Ingvar, M.; Persson, J.; Cruts, M.; Nilsson, Lars-Gö ...

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