Sökning: WFRF:(Skene Debra J) >
Exogenous melatonin...
Exogenous melatonin decreases circadian misalignment and body weight among early types
-
Marqueze, Elaine C. (författare)
-
Nogueira, Luciana F. R. (författare)
-
Vetter, Céline (författare)
-
visa fler...
-
Skene, Debra J. (författare)
-
Cipolla-Neto, José (författare)
-
- Moreno, Claudia R. C. (författare)
- Stockholms universitet,Stressforskningsinstitutet,University of São Paulo, Brazil
-
visa färre...
-
(creator_code:org_t)
- 2021-06-20
- 2021
- Engelska.
-
Ingår i: Journal of Pineal Research. - : Wiley. - 0742-3098 .- 1600-079X. ; 71:2
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Shift workers experience chronic circadian misalignment, which can manifest itself in reduced melatonin production, and has been associated with metabolic disorders. In addition, chronotype modulates the effect of night shift work, with early types presenting greater circadian misalignment when working night shift as compared to late types. Melatonin supplementation has shown positive results reducing weight gain in animal models, but the effect of exogenous melatonin in humans on body weight in the context of shift work remains inconsistent. The aim of this study was thus to evaluate the effects of exogenous melatonin on circadian misalignment and body weight among overweight night shift workers, according to chronotype, under real-life conditions. We conducted a double-blind, randomized, placebo-controlled, crossover trial where melatonin (3 mg) or placebo was administered on non-night shift nights for 12 weeks in 27 female nurses (37.1 yo, +/- 5.9 yo; BMI 29.9 kg/m(2), +/- 3.3 kg/m(2)). Melatonin (or placebo) was only taken on nights when the participants did not work night shifts, that is, on nights when they slept (between night shifts and on days off). Composite Phase Deviations (CPD) of actigraphy-based mid-sleep timing were calculated to measure circadian misalignment. The analyses were performed for the whole group and by chronotype. We found approximately 20% reduction in circadian misalignment after exogenous melatonin administration considering all chronotypes. Moreover, melatonin supplementation in those who presented high circadian misalignment, as observed in early chronotypes, reduced body weight, BMI, waist circumference, and hip circumference, without any change in the participants' calorie intake or physical activity levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- circadian rhythm disorders
- dietary supplements
- melatonin
- night shift work
- nursing staff
- overweight
- working women
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas