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  • Tamm, SandraKarolinska Institutet (författare)

Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy : Preliminary Assessments of the Role of Sickness, Central and Peripheral Inflammation

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Dove Medical Press,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-196435
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-196435URI
  • https://doi.org/10.2147/NSS.S297702DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449255URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146992177URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The study was supported by grants from Hedlund Foundation (M.L., C.O.H.), Karolinska Institute (M.L., E.K., C.O.H.), the Hjärt-Lungfonden (M.L., C.O.H., B.K.), Swedish Asthma and Allergy Association (C.O.H., M.L.), the Swedish Research Council (M.L, E.K., J.L., B.K.), Center for Allergy Research (M.L., C.O.H.), Stockholm Stress Center (M.L., C.O. H.), Isabella and Henrik Berg and Heumanska stiftelsen/Hjärnfonden (M.L.), Per and Ingrid Nydahl (S.T.), Osher Center for Integrative Medicine (M.L., C. O.H.), Swedish Council for Working Life and Social Research (M.L., C.O.H.), The European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreements No. 602919 (E.K.), Swedish Foundation for Strategic Research, Stockholm County Council (E.K.) and a donation from the Lundblad family (E.K.).
  • Introduction: Disturbed sleep in inflammatory disorders such as allergy and rheumatoid arthritis (RA) is common and may be directly or indirectly related to disease processes, but has not been well characterized in these patient groups, especially not with objective methods.Aim: The present study aimed to characterize objective and subjective sleep in patients with allergy or RA using sleep diaries, one-channel EEG and actigraphy. It also aimed to investigate if sleep measures were associated with central immune activation, assessed using translocator protein (TSPO) positron emission tomography, as well as cytokine markers of peripheral inflammation and disease-specific symptoms or general symptoms of sickness.Methods: In total, 18 patients with seasonal pollen allergy, 18 patients with RA and 26 healthy controls were included in the study. Allergy patients and matched controls were assessed twice, in and out of pollen season, and RA patients and controls were assessed once. Sleep was recorded for approximately 1 week at each occasion.Results: Patients with allergy had increased levels of slow-wave sleep during pollen season. In contrast, patients with RA had less SWS compared to healthy controls, while no differences were observed in sleep duration or subjective sleep quality. Across groups, neither proinflammatory cytokines, grey matter TSPO levels nor general sickness symptoms were associated with objective or subjective measures of sleep. Rhinitis, but not conjunctivitis, was correlated to worse subjective sleep and more slow wave sleep in allergy. Functional status, but not disease activity, predicted lower subjective sleep in RA.Conclusion: This study tentatively indicates that both patients with allergy and RA display sleep alterations but does not support inflammation as an independent predictor of the sleep disturbance across these patient groups.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lensmar, CatarinaKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. (författare)
  • Andreasson, AnnaKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.(Swepub:su)anan6088 (författare)
  • Axelsson, JohnStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.(Swepub:su)jaxel (författare)
  • Forsberg Morén, AntonKarolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Hlth Care Serv, Stockholm, Region Stockhol, Sweden. (författare)
  • Grunewald, JohanKarolinska Institutet (författare)
  • Gyllfors, PärSt Gorans Univ Hosp, Asthma & Allergy Clin, Stockholm, Sweden. (författare)
  • Karshikoff, BiankaStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.(Swepub:su)bilo2727 (författare)
  • Kosek, EvaKarolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.(Swepub:uu)evako353 (författare)
  • Lampa, JonKarolinska Institutet (författare)
  • Olgart Höglund, CarolineKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Inst, Dept Med, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (författare)
  • Strand, VictoriaSt Gorans Univ Hosp, Asthma & Allergy Clin, Stockholm, Sweden. (författare)
  • Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (författare)
  • Lekander, MatsStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.(Swepub:su)mleka (författare)
  • Karolinska InstitutetKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature and Science of Sleep: Dove Medical Press13, s. 775-7891179-1608

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