Sökning: WFRF:(Kull Inger)
> (2020-2024) >
SARS-CoV-2-specific...
SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults
-
- Björkander, Sophia (författare)
- Karolinska Institutet
-
- Du, Likun (författare)
- Karolinska Institutet
-
- Zuo, Fanglei (författare)
- Karolinska Institutet
-
visa fler...
-
- Ekström, Sandra (författare)
- Karolinska Institutet
-
- Wang, Yating (författare)
- Karolinska Institutet
-
- Wan, Hui (författare)
- Karolinska Institutet
-
Sherina, Natalia (författare)
-
Schoutens, Lisanne (författare)
-
- Andréll, Juni (författare)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik
-
- Andersson, Niklas (författare)
- Karolinska Institutet
-
- Georgelis, Antonios (författare)
- Karolinska Institutet
-
- Bergström, Anna (författare)
- Karolinska Institutet
-
- Marcotte, Harold (författare)
- Karolinska Institutet
-
- Kull, Inger (författare)
- Karolinska Institutet
-
- Hammarström, Lennart (författare)
- Karolinska Institutet
-
- Melén, Erik (författare)
- Karolinska Institutet
-
- Pan-Hammarström, Qiang (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
-
Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 149:1, s. 65-75
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
http://www.jacionlin...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear.Objective: We conducted a population-based study on humoral and cellular immunity to SARS-CoV-2 and explored COVID-19 disease characteristics in young adults.Methods: We invited participants from the Swedish BAMSE (Barn [Children], Allergy Milieu, Stockholm, Epidemiology) birth cohort (age 24-27 years) to take part in a COVID-19 followup. From 980 participants (October 2020 to June 2021), we here present data on SARS-CoV-2 receptor-binding domain-specific IgM, IgA, and IgG titers measured by ELISA and on symptoms and epidemiologic factors associated with seropositivity. Further, SARS-CoV-2-specific memory B-and T-cell responses were detected for a subpopulation (n 5 108) by ELISpot and FluoroSpot.Results: A total of 28.4% of subjects were seropositive, of whom 18.4% were IgM single positive. One in 7 seropositive subjects was asymptomatic. Seropositivity was associated with use of public transport, but not with sex, asthma, rhinitis, IgE sensitization, smoking, or body mass index. In a subset of representative samples, 20.7% and 35.0% had detectable SARSCoV-2 specific B-and T-cell responses, respectively. B-and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.Conclusions: Assessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults indicates that the large-scale vaccination campaign should be continued. (J Allergy Clin Immunol 2022;149:65-75.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- SARS-CoV-2
- COVID-19 disease
- IgM
- IgA
- IgG
- mem-ory T cells
- memory B cells
- young adults
- population-based cohort
- asthma
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Björkander, Soph ...
-
Du, Likun
-
Zuo, Fanglei
-
Ekström, Sandra
-
Wang, Yating
-
Wan, Hui
-
visa fler...
-
Sherina, Natalia
-
Schoutens, Lisan ...
-
Andréll, Juni
-
Andersson, Nikla ...
-
Georgelis, Anton ...
-
Bergström, Anna
-
Marcotte, Harold
-
Kull, Inger
-
Hammarström, Len ...
-
Melén, Erik
-
Pan-Hammarström, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Journal of Aller ...
- Av lärosätet
-
Stockholms universitet
-
Karolinska Institutet