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Neuroprotective eff...
Neuroprotective effects of insulin like growth factor-1 on engineered metal nanoparticles Ag, Cu and Al induced blood-brain barrier breakdown, edema formation, oxidative stress, upregulation of neuronal nitric oxide synthase and brain pathology
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- Sharma, Hari Shanker (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Vicente Lafuente, José (författare)
- Univ Basque Country, UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain.
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- Muresanu, Dafin F. (författare)
- Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
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- Sahib, Seaab (författare)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Tian, Z. Ryan (författare)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Menon, Preeti K., 1988- (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.
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- Castellani, Rudy J. (författare)
- Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
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- Nozari, Ala (författare)
- Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA.
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- Buzoianu, Anca D. (författare)
- Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania.
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- Sjöquist, Per-Ove (författare)
- Karolinska Inst, Karolinska Univ Hosp, Dept Med, Div Cardiol, Stockholm, Sweden.
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- Patnaik, Ranjana (författare)
- Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India.
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- Wiklund, Lars (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Aruna (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Progress in Brain Research. - : Elsevier. - 0079-6123 .- 1875-7855. ; 266, s. 97-121, s. 97-121
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Military personnel are vulnerable to environmental or industrial exposure of engineered nanoparticles (NPs) from metals. Long-term exposure of NPs from various sources affect sensory-motor or cognitive brain functions. Thus, a possibility exists that chronic exposure of NPs affect blood-brain barrier (BBB) breakdown and brain pathology by inducing oxidative stress and/or nitric oxide production. This hypothesis was examined in the rat intoxicated with Ag, Cu or Al (50–60 nm) nanoparticles (50 mg/kg, i.p. once daily) for 7 days. In these NPs treated rats the BBB permeability, brain edema, neuronal nitric oxide synthase (nNOS) immunoreactivity and brain oxidants levels, e.g., myeloperoxidase (MP), malondialdehyde (MD) and glutathione (GT) was examined on the 8th day. Cu and Ag but not Al nanoparticles increased the MP and MD levels by twofold in the brain although, GT showed 50% decline. At this time increase in brain water content and BBB breakdown to protein tracers were seen in areas exhibiting nNOS positive neurons and cell injuries. Pretreatment with insulin like growth factor-1 (IGF-1) in high doses (1 μg/kg, i.v. but not 0.5 μg/kg daily for 7 days) together with NPs significantly reduced the oxidative stress, nNOS upregulation, BBB breakdown, edema formation and cell injuries. These novel observations demonstrate that (i) NPs depending on their metal constituent (Cu, Ag but not Al) induce oxidative stress and nNOS expression leading to BBB disruption, brain edema and cell damage, and (ii) IGF-1 depending on doses exerts powerful neuroprotection against nanoneurotoxicity, not reported earlier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Nanoparticles
- Oxidative stress
- Nitric oxide
- Cell injury
- Insulin like growth factor-1 (IGF-1)
- Brain edema
- Cu
- Al
- Ag
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sharma, Hari Sha ...
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Vicente Lafuente ...
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Muresanu, Dafin ...
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Sahib, Seaab
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Tian, Z. Ryan
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Menon, Preeti K. ...
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visa fler...
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Castellani, Rudy ...
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Nozari, Ala
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Buzoianu, Anca D ...
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Sjöquist, Per-Ov ...
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Patnaik, Ranjana
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Wiklund, Lars
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Sharma, Aruna
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Progress in Brai ...
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Brain protection ...
- Av lärosätet
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Stockholms universitet
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Uppsala universitet
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Karolinska Institutet