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Improvement in indi...
Improvement in indices of cellular protection after psychological treatment for social anxiety disorder
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- Månsson, Kristoffer N. T. (author)
- Karolinska Institutet,Uppsala universitet,Uppsala University,Stockholm University,Karolinska Institute,Stockholms universitet,Klinisk psykologi,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, Stockholm University, Stockholm, Sweden; Department of Psychology, Uppsala University, Uppsala, Sweden,Karolinska Inst, Sweden; Stockholm Univ, Sweden; Uppsala Univ, Sweden,Institutionen för psykologi
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- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Unit for clinical suicide research,Lund University Research Groups,Unit for Biological and Precision Psychiatry
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- Yang, Liu L. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Svanborg, Cecilia (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- Isung, Josef (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- Nilsonne, Gustav (author)
- Karolinska Institutet,Stockholm University,Karolinska Institute,Stockholms universitet,Stressforskningsinstitutet,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden,Karolinska Inst, Sweden; Stockholm Univ, Sweden
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- Bergman Nordgren, Lise, 1983- (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- El Alaoui, Samir (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- Hedman-Lagerlöf, Erik (author)
- Karolinska Institutet,Karolinska Institute
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- Kraepelien, Martin (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- Högström, Jens (author)
- Karolinska Institutet,Karolinska Institute,Stockholms läns sjukvårdsområde
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- Andersson, Gerhard, Fil dr, Med dr, 1966- (author)
- Karolinska Institutet,Linköping University,Karolinska Institute,Linköpings universitet,Psykologi,Filosofiska fakulteten,Karolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden,Stockholms läns sjukvårdsområde
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- Boraxbekk, Carl-Johan, 1980- (author)
- Umeå University,Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR),Center for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark,Umea Univ, Sweden; Copenhagen Univ Hosp, Denmark
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- Fischer, Håkan (author)
- Stockholm University,Stockholms universitet,Biologisk psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden,Stockholm Univ, Sweden
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- Lavebratt, Catharina (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wolkowitz, Owen M. (author)
- Department of Psychiatry, University of California, San Francisco, CA, USA,Univ Calif San Francisco, CA USA
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- Furmark, Tomas (author)
- Uppsala universitet,Uppsala University,Institutionen för psykologi
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(creator_code:org_t)
- 2019-12-19
- 2019
- English.
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In: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1
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Abstract
Subject headings
Close
- Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- telomere attrition
- cellular protection
- psychological treatment
- social anxiety disorder
- Psychology
- psykologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Månsson, Kristof ...
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Lindqvist, Danie ...
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Yang, Liu L.
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Svanborg, Cecili ...
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Isung, Josef
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Nilsonne, Gustav
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Bergman Nordgren ...
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El Alaoui, Samir
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Hedman-Lagerlöf, ...
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Kraepelien, Mart ...
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Högström, Jens
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Andersson, Gerha ...
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Boraxbekk, Carl- ...
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Fischer, Håkan
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Lavebratt, Catha ...
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Wolkowitz, Owen ...
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Furmark, Tomas
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Translational Ps ...
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Stockholm University
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Örebro University
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Umeå University
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Linköping University
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Lund University
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Uppsala University
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Karolinska Institutet
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