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Autocrine signaling...
Autocrine signaling can explain the emergence of Allee effects in cancer cell populations
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- Gerlee, Philip, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Math Sci, Gothenburg, Sweden.;Univ Gothenburg, Math Sci, Gothenburg, Sweden.
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- Altrock, P. M. (författare)
- H. Lee Moffitt Cancer Center and Research Institute,H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL USA.;Max Planck Inst Evolutionary Biol, Dept Evolutionary Theory, Plon, Germany.
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- Malik, Adam (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Krona, Cecilia, 1976- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Nelander, Sven (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- 2022-03-03
- 2022
- Engelska.
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Ingår i: Plos Computational Biology. - : Public Library of Science (PLoS). - 1553-734X .- 1553-7358. ; 18:3
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Abstract
Ämnesord
Stäng
- In many human cancers, the rate of cell growth depends crucially on the size of the tumour cell population. Low, zero, or negative growth at low population densities is known as the Allee effect; this effect has been studied extensively in ecology, but so far lacks a good explanation in the cancer setting. Here, we formulate and analyze an individual-based model of cancer, in which cell division rates are increased by the local concentration of an autocrine growth factor produced by the cancer cells themselves. We show, analytically and by simulation, that autocrine signaling suffices to cause both strong and weak Allee effects. Whether low cell densities lead to negative (strong effect) or reduced (weak effect) growth rate depends directly on the ratio of cell death to proliferation, and indirectly on cellular dispersal. Our model is consistent with experimental observations from three patient-derived brain tumor cell lines grown at different densities. We propose that further studying and quantifying population-wide feedback, impacting cell growth, will be central for advancing our understanding of cancer dynamics and treatment, potentially exploiting Allee effects for therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- proliferation
- heterogeneity
- evolutionary
- dynamics
- invasion
- Biochemistry & Molecular Biology
- Mathematical & Computational Biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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