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  • Chen, Hui (author)

Association of Long-Term Body Weight Variability With Dementia : A Prospective Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-12-15
  • Oxford University Press (OUP),2021
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:su-204715
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-204715URI
  • https://doi.org/10.1093/gerona/glab372DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149448430URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.Methods: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).Results: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis.Conclusion: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.

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  • Zhou, Tianjing (author)
  • Guo, JieKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Ji, John S. (author)
  • Huang, Liyan (author)
  • Xu, WeiliKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China (author)
  • Zuo, Guangmin (author)
  • Lv, Xiaozhen (author)
  • Zheng, Yan (author)
  • Hofman, Albert (author)
  • Ma, Yuan (author)
  • Yuan, Changzheng (author)
  • Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:The journals of gerontology. Series A, Biological sciences and medical sciences: Oxford University Press (OUP)77:10, s. 2116-21221079-50061758-535X

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