Search: id:"swepub:oai:DiVA.org:su-204715" >
Association of Long...
Association of Long-Term Body Weight Variability With Dementia : A Prospective Study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-12-15
-
Oxford University Press (OUP),2021
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-204715
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-204715URI
-
https://doi.org/10.1093/gerona/glab372DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:149448430URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.Methods: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).Results: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis.Conclusion: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Zhou, Tianjing
(author)
-
Guo, JieKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
-
Ji, John S.
(author)
-
Huang, Liyan
(author)
-
Xu, WeiliKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China
(author)
-
Zuo, Guangmin
(author)
-
Lv, Xiaozhen
(author)
-
Zheng, Yan
(author)
-
Hofman, Albert
(author)
-
Ma, Yuan
(author)
-
Yuan, Changzheng
(author)
-
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Related titles
-
In:The journals of gerontology. Series A, Biological sciences and medical sciences: Oxford University Press (OUP)77:10, s. 2116-21221079-50061758-535X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Chen, Hui
-
Zhou, Tianjing
-
Guo, Jie
-
Ji, John S.
-
Huang, Liyan
-
Xu, Weili
-
show more...
-
Zuo, Guangmin
-
Lv, Xiaozhen
-
Zheng, Yan
-
Hofman, Albert
-
Ma, Yuan
-
Yuan, Changzheng
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
The journals of ...
- By the university
-
Stockholm University
-
Karolinska Institutet