WFRF:(Le Duc G)
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- Le Duc, D. (author)
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- American Association for the Advancement of Science (AAAS),2022
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-206281
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-206281URI
- https://doi.org/10.1126/sciadv.abl6496DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold aquatic (or marine) environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis, a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. We also found that Steller's sea cows' abundance was continuously declining for tens of thousands of years before their description, implying that environmental changes also contributed to their extinction.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Mammals
- Aquatic environments
- Convergent evolution
- Environmental change
- Genomics
- Human modelling
- Lipoxygenases
- Marine environment
- Mice models
- Skin disease
- Genes
- animal
- bovine
- Dugong
- female
- mammal
- mouse
- phenotype
- Animals
- Cattle
- Mice
Added entries (persons, corporate bodies, meetings, titles ...)
- Velluva, A. (author)
- Cassatt-Johnstone, M. (author)
- Olsen, Remi-AndréStockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik(Swepub:su)rolse (author)
- Baleka, S. (author)
- Lin, C.-C. (author)
- Lemke, J. R. (author)
- Southon, J. R. (author)
- Burdin, A. (author)
- Wang, M.-S. (author)
- Grunewald, S. (author)
- Rosendahl, W. (author)
- Joger, U. (author)
- Rutschmann, S. (author)
- Hildebrandt, T. B. (author)
- Fritsch, G. (author)
- Estes, J. A. (author)
- Kelso, J. (author)
- Dalén, Love,1980-Stockholms universitet,Zoologiska institutionen,Swedish Museum of Natural History, Sweden(Swepub:su)dalen (author)
- Hofreiter, M. (author)
- Shapiro, B. (author)
- Schöneberg, T. (author)
- Stockholms universitetScience for Life Laboratory (SciLifeLab) (creator_code:org_t)
Related titles
- In:Science Advances: American Association for the Advancement of Science (AAAS)8:52375-2548
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- Lemke, J. R.
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