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  • Rothwell, Joseph A.Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France (author)

Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191349
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191349URI
  • https://doi.org/10.1016/j.cgh.2020.11.045DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.

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  • Murphy, NeilInternational Agency for Research on Cancer, Lyon, France (author)
  • Bešević, JelenaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Kliemann, NathalieInternational Agency for Research on Cancer, Lyon, France (author)
  • Jenab, MazdaInternational Agency for Research on Cancer, Lyon, France (author)
  • Ferrari, PietroInternational Agency for Research on Cancer, Lyon, France (author)
  • Achaintre, DavidInternational Agency for Research on Cancer, Lyon, France (author)
  • Gicquiau, AudreyInternational Agency for Research on Cancer, Lyon, France (author)
  • Vozar, BéatriceInternational Agency for Research on Cancer, Lyon, France (author)
  • Scalbert, AugustinInternational Agency for Research on Cancer, Lyon, France (author)
  • Huybrechts, IngeInternational Agency for Research on Cancer, Lyon, France (author)
  • Freisling, HeinzInternational Agency for Research on Cancer, Lyon, France (author)
  • Prehn, CorneliaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Adamski, JerzyResearch Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany (author)
  • Cross, Amanda J.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Pala, Valeria MariaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Boutron-Ruault, Marie-ChristineCentre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France (author)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus C, Denmark (author)
  • Overvad, KimDepartment of Public Health, Aarhus University, Aarhus C, Denmark (author)
  • Gram, Inger TorhildFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (author)
  • Sandanger, Torkjel M.Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (author)
  • Skeie, GuriFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (author)
  • Jakszyn, PaulaUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain (author)
  • Tsilidis, Kostas K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece (author)
  • Aleksandrova, KrasimiraNutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (author)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (author)
  • Hughes, David J.School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland (author)
  • van Guelpen, BethanyUmeå universitet,Onkologi(Swepub:umu)beyvan99 (author)
  • Bodén, StinaUmeå universitet,Onkologi(Swepub:umu)stabon98 (author)
  • Sánchez, Maria-JoséCIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (author)
  • Schmidt, Julie A.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (author)
  • Katzke, VerenaDivision of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany (author)
  • Kühn, TilmanDivision of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany (author)
  • Colorado-Yohar, SandraDepartment of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (author)
  • Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy (author)
  • Bueno-de-Mesquita, BasDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands (author)
  • Vineis, PaoloDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy (author)
  • Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy (author)
  • Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (author)
  • Eriksen, Anne KirstineDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark (author)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark (author)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, Lyon, France (author)
  • Severi, GianlucaCentre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France (author)
  • Chajès, VéroniqueInternational Agency for Research on Cancer, Lyon, France (author)
  • Gunter, Marc J.International Agency for Research on Cancer, Lyon, France (author)
  • Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, FranceInternational Agency for Research on Cancer, Lyon, France (creator_code:org_t)

Related titles

  • In:Clinical Gastroenterology and Hepatology: Elsevier20:5, s. e1061-e10821542-35651542-7714

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