WFRF:(Andersson Claes 1987)
Search: WFRF:(Andersson Claes 1987) > Single-cell transcr...
- 15 of 16
- Previous record
- Next record
- To hitlist
- Selvin, ToveUppsala universitet,Cancerfarmakologi och beräkningsmedicin (author)
Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-07-13
- Springer Science and Business Media LLC,2022
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-207953
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-207953URI
- https://doi.org/10.1038/s41598-022-16077-7DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481692URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Understanding the immunological effects of chemotherapy is of great importance, especially now that we have entered an era where ever-increasing pre-clinical and clinical efforts are put into combining chemotherapy and immunotherapy to combat cancer. Single-cell RNA sequencing (scRNA-seq) has proved to be a powerful technique with a broad range of applications, studies evaluating drug effects in co-cultures of tumor and immune cells are however scarce. We treated a co-culture comprised of human colorectal cancer (CRC) cells and peripheral blood mononuclear cells (PBMCs) with the nucleoside analogue trifluridine (FTD) and used scRNA-seq to analyze posttreatment gene expression profiles in thousands of individual cancer and immune cells concurrently. ScRNA-seq recapitulated major mechanisms of action previously described for FTD and provided new insight into possible treatment-induced effects on T-cell mediated antitumor responses.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Fasterius, Erik,1987-Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Natl Bioinformat Infrastruct Sweden NBIS, Stockholm, Sweden.(Swepub:su)erfa2214 (author)
- Jarvius, MalinUppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)maemi734 (author)
- Fryknäs, MårtenUppsala universitet,Cancerfarmakologi och beräkningsmedicin(Swepub:uu)mafry516 (author)
- Larsson, RolfUppsala universitet,Cancerfarmakologi och beräkningsmedicin,Klinisk immunologi(Swepub:uu)rolflars (author)
- Andersson, ClaesUppsala universitet,Cancerfarmakologi och beräkningsmedicin(Swepub:uu)cland109 (author)
- Uppsala universitetCancerfarmakologi och beräkningsmedicin (creator_code:org_t)
Related titles
- In:Scientific Reports: Springer Science and Business Media LLC122045-2322
Internet link
Find in a library
- Scientific Reports (Search for host publication in LIBRIS)
To the university's database
- 15 of 16
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Selvin, Tove
- Fasterius, Erik, ...
- Jarvius, Malin
- Fryknäs, Mårten
- Larsson, Rolf
- Andersson, Claes
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Scientific Repor ...
- By the university
- Stockholm University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
