Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes: An Overview

Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes : An Overview

Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structure. Gram-negative bacteria have an additional outer membrane (OM) that is not present in their gram-positive counterpart; the latter instead hold a thicker peptidoglycan (PG) layer. This review covers the main structural and functional properties of cell wall polysaccharides (CWPs) and PG. Drugs targeting CWPs are discussed, both noncarbohydrate-related (β-lactams, fosfomycin, and lipopeptides) and carbohydrate-related (glycopeptides and lipoglycopeptides). Bacterial resistance to these drugs continues to evolve, which calls for novel antibacterial approaches to be developed. The use of carbohydrate-based vaccines as a valid strategy to prevent bacterial infections is also addressed.

Ruda, Alessandro,1990-Stockholms universitet,Institutionen för organisk kemi(Swepub:su)alru3031 (author)
Ibba, Roberta (author)
Sestito, Simona (author)
Lupinu, Ilenia (author)
Piras, Sandra (author)
Widmalm, GöranStockholms universitet,Institutionen för organisk kemi(Swepub:su)gw (author)
Carta, Antonio (author)
Stockholms universitetInstitutionen för organisk kemi (creator_code:org_t)

By the author/editor: Riu, Federico; Ruda, Alessandro ...; Ibba, Roberta; Sestito, Simona; Lupinu, Ilenia; Piras, Sandra; show more...; Widmalm, Göran; Carta, Antonio; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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