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Chemistry and the P...
Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.;Int Joint Res Lab Intelligent Agr & Agriprod Proc, Gsu Educ Dept, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Yosri, Nermeen (författare)
- Beni Suef Univ, Res Inst Med & Aromat Plants RIMAP, Chem Dept Med & Aromat Plants, Bani Suwayf 62514, Egypt.;Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
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- El-Aarag, Bishoy (författare)
- Menoufia Univ, Fac Sci, Chem Dept, Biochem Div, Shibin Al Kawm 32512, Egypt.;Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Okayama 7008530, Japan.;Chapman Univ, Ctr Targeted Drug Delivery, Dept Biomed & Pharmaceut Sci, Sch Pharm, Harry & Diane Rinker Hlth Sci Campus, Irvine, CA 92618 USA.
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- Mahmoud, Shaymaa H. (författare)
- Menoufia Univ, Fac Sci, Zool Dept, Shibin Al Kawm 32512, Egypt.
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- Zayed, Ahmed (författare)
- Tanta Univ, Coll Pharm, Pharmacognosy Dept, Elguish St, Tanta 31527, Egypt.,Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.
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- Du, Ming (författare)
- Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116024, Peoples R China.
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Saeed, Aamer (författare)
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- Musharraf, Syed G. (författare)
- Univ Karachi, Int Ctr Chem & Biol Sci ICCBS, HEJ Res Inst Chem, Karachi 75270, Pakistan.
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- El-Garawani, Islam M. (författare)
- Menoufia Univ, Fac Sci, Zool Dept, Shibin Al Kawm 32512, Egypt.
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- Habib, Mohamed R. (författare)
- Theodor Bilharz Res Inst, Med Malacol Dept, Giza 12411, Egypt.
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- Tahir, Haroon Elrasheid (författare)
- Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Hegab, Momtaz M. (författare)
- Beni Suef Univ, Res Inst Med & Aromat Plants RIMAP, Chem Dept Med & Aromat Plants, Bani Suwayf 62514, Egypt.
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- Zou, Xiaobo (författare)
- Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Guo, Zhiming (författare)
- Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Efferth, Thomas (författare)
- Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Dept Pharmaceut Biol, D-55128 Mainz, Germany.
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- Khalifa, Shaden A. M. (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.
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(creator_code:org_t)
- 2022-10-05
- 2022
- Engelska.
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Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 27:19
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such as plants, herbs, and marines. It is well known that cardiotonic steroids reveal effects against congestive heart failure and atrial fibrillation; therefore, the term cardiotonic has been coined. Cardiotonic steroids are divided into two distinct groups: cardenolides (plant-derived) and bufadienolides (mainly of animal origin). Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. Cancer is a leading cause of mortality in humans all over the world. In 2040, the global cancer load is expected to be 28.4 million cases, which would be a 47% increase from 2020. Moreover, viruses and inflammations also have a very nebative impact on human health and lead to mortality. In the current review, we focus on the chemistry, antiviral and anti-cancer activities of cardiotonic steroids from the naturally derived (toads) venom to combat these chronic devastating health problems. The databases of different research engines (Google Scholar, PubMed, Science Direct, and Sci-Finder) were screened using different combinations of the following terms: cardiotonic steroids, anti-inflammatory, antiviral, anticancer, toad venom, bufadienolides, and poison chemical composition. Various cardiotonic steroids were isolated from diverse toad species and exhibited superior anti-inflammatory, anticancer, and antiviral activities in in vivo and in vitro models such as marinobufagenin, gammabufotalin, resibufogenin, and bufalin. These steroids are especially difficult to identify. However, several compounds and their bioactivities were identified by using different molecular and biotechnological techniques. Biotechnology is a new tool to fully or partially generate upscaled quantities of natural products, which are otherwise only available at trace amounts in organisms.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- anticancer
- antiviral
- anti-inflammatory
- cardiotonic steroids
- bufadienolides
- bufotalin
- bufalin
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El-Seedi, Hesham
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Yosri, Nermeen
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El-Aarag, Bishoy
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Mahmoud, Shaymaa ...
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Zayed, Ahmed
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Du, Ming
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Saeed, Aamer
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Musharraf, Syed ...
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El-Garawani, Isl ...
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Habib, Mohamed R ...
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Tahir, Haroon El ...
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Hegab, Momtaz M.
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Zou, Xiaobo
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Guo, Zhiming
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Efferth, Thomas
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Khalifa, Shaden ...
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- NATURVETENSKAP
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NATURVETENSKAP
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- NATURVETENSKAP
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NATURVETENSKAP
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Molecules
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Stockholms universitet
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Uppsala universitet