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Long term exposure ...
Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution : a Study in Europe (ELAPSE)
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- Hvidtfeldt, Ulla Arthur (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Taj, Tahir, 1982- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Danish Cancer Society Research Center, Copenhagen, Denmark; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden,Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Chen, Jie (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
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- Rodopoulou, Sophia (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- Strak, Maciej (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands
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- de Hoogh, Kees (författare)
- Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland
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- Andersen, Zorana J. (författare)
- Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Bellander, Tom (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
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- Brandt, Jørgen (författare)
- Department of Environmental Science, Aarhus University, Roskilde, Denmark; Climate – Interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark
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- Fecht, Daniela (författare)
- MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
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- Forastiere, Francesco (författare)
- Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College, London, UK
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- Gulliver, John (författare)
- MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, UK
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- Hertel, Ole (författare)
- Departments of Ecoscience, Aarhus University, Roskilde, Denmark
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- Hoffmann, Barbara (författare)
- Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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Jørgensen, Jeanette T. (författare)
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- Katsouyanni, Klea (författare)
- Karolinska Institutet
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- Ketzel, Matthias (författare)
- Department of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford GU2 7XH, United Kingdom
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- Lager, Anton (författare)
- Karolinska Institutet
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- Leander, Karin (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Ljungman, Petter (författare)
- Karolinska Institutet
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Magnusson, Patrik K. E. (författare)
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- Nagel, Gabriele (författare)
- Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
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- Pershagen, Göran (författare)
- Karolinska Institutet
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- Rizzuto, Debora (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden
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- Samoli, Evangelia (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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- So, Rina (författare)
- Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Stafoggia, Massimo (författare)
- i Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Vermeulen, Roel (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
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- Weinmayr, Gudrun (författare)
- Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
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- Wolf, Kathrin (författare)
- Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
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- Zhang, Jiawei (författare)
- Section of Environment and Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Zitt, Emanuel (författare)
- Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria
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- Brunekreef, Bert (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
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- Hoek, Gerard (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
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- Raaschou-Nielsen, Ole (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Roskilde, Denmark
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(creator_code:org_t)
- Academic Press Inc. 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Academic Press Inc.. - 0013-9351 .- 1096-0953. ; 215
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985–2005) to 2011–2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5–95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8–39.2), 15.3 μg/m3 (8.6–19.2), 1.6 10−5 m−1 (0.7–2.1), and 87.0 μg/m3 (70.3–97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10−5 m−1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- air Pollution
- Kidney cancer incidence
- Nitrogen dioxide
- Ozone
- Particulate matter
- PM elemental Components
- black carbon
- copper
- iron
- nickel
- potassium
- silicon
- sulfur
- trace metal
- vanadium
- zinc
- carbon
- carcinogen
- ambient air
- atmospheric pollution
- cancer
- confidence interval
- DNA
- pollution exposure
- adult
- Article
- body mass
- cancer incidence
- cancer registry
- cohort analysis
- controlled study
- European
- female
- follow up
- human
- ICD-9
- kidney cancer
- kidney parenchyma
- long term exposure
- major clinical study
- male
- obesity
- PM2.5 exposure
- proportional hazards model
- residential area
- season
- adverse event
- air pollutant
- analysis
- environmental exposure
- Europe
- exhaust gas
- kidney
- kidney tumor
- soot
- toxicity
- Air Pollutants
- Carcinogens
- Humans
- Kidney Neoplasms
- Vehicle Emissions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hvidtfeldt, Ulla ...
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Taj, Tahir, 1982 ...
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Chen, Jie
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Rodopoulou, Soph ...
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Strak, Maciej
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de Hoogh, Kees
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visa fler...
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Andersen, Zorana ...
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Bellander, Tom
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Brandt, Jørgen
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Fecht, Daniela
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Forastiere, Fran ...
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Gulliver, John
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Hertel, Ole
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Hoffmann, Barbar ...
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Jørgensen, Jeane ...
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Katsouyanni, Kle ...
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Ketzel, Matthias
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Lager, Anton
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Leander, Karin
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Ljungman, Petter
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Magnusson, Patri ...
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Nagel, Gabriele
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Pershagen, Göran
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Rizzuto, Debora
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Samoli, Evangeli ...
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So, Rina
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Stafoggia, Massi ...
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Tjønneland, Anne
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Vermeulen, Roel
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Weinmayr, Gudrun
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Wolf, Kathrin
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Zhang, Jiawei
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Zitt, Emanuel
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Brunekreef, Bert
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Hoek, Gerard
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Raaschou-Nielsen ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Stockholms universitet
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Örebro universitet
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Karolinska Institutet