Sökning: WFRF:(Gay J)
> (2020-2024) >
Biological use infl...
Biological use influences the impact of inflammation on risk of major adverse cardiovascular events in rheumatoid arthritis
-
- Karpouzas, George Athanasios (författare)
- Internal Medicine - Rheumatology, CA, Torrance, United States; Harbor-UCLA Medical Center, Rheumatology, CA, Torrance, United States
-
- Ormseth, Sarah R. (författare)
- CA, Torrance, United States
-
- van Riel, Piet Leonardus Cornelis Maria (författare)
- IQ Healthcare, Radboud University, Gelderland, Nijmegen, Netherlands; Bernhoven Hospital Location Oss, Rheumatology, Oss, Netherlands
-
visa fler...
-
- Gonzalez-Gay, Miguel A. (författare)
- Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain; IIS-Fundacion Jimenez Diaz, Madrid, Spain
-
- Corrales, Alfonso (författare)
- Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
-
- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå universitet,Reumatologi
-
- Sfikakis, Petros P. (författare)
- First Dept. of Propedeutic Medicine, University of Athens, Attica, Athens, Greece
-
- Dessein, Patrick (författare)
- School of Physiology, University of the Witwatersrand Johannesburg, Johannesburg, South Africa
-
- Tsang, Linda (författare)
- Vrije Universiteit Brussel, Belgium
-
- Hitchon, Carol (författare)
- University of Manitoba, Rheumatology, MB, Winnipeg, Canada
-
- El-Gabalawy, Hani (författare)
- Department of Internal Medicine, University of Manitoba, MB, Winnipeg, Canada
-
- Pascual-Ramos, Virginia (författare)
- Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
-
- Contreras-Yáñez, Irazú (författare)
- Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico
-
- Colunga-Pedraza, Iris J. (författare)
- Hospital Universitario Dr José Eleuterio González, Rheumatology, Nuevo León, Monterrey, Mexico
-
- Galarza-Delgado, Dionicio Angel (författare)
- Hospital Universitario Dr Jose Eleuterio Gonzalez, Rheumatology, Nuevo León, Monterrey, Mexico
-
- Azpiri-Lopez, Jose Ramon (författare)
- Hospital Universitario Dr José Eleuterio González, Nuevo León, Monterrey, Mexico
-
- Semb, Anne Grete (författare)
- Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway
-
- Misra, Durga Prasanna (författare)
- Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, Lucknow, India
-
- Hauge, Ellen-Margrethe (författare)
- Department of Joint and Connective Tissue Diseases, Aarhus Universitetshospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus Universitet, Aarhus, Denmark
-
- Kitas, George (författare)
- Department of Rheumatology, Dudley Group NHS Foundation Trust, West Midlands, Dudley, United Kingdom
-
visa färre...
-
(creator_code:org_t)
- BMJ Publishing Group Ltd, 2024
- 2024
- Engelska.
-
Ingår i: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 10:3
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: Chronic inflammation promotes cardiovascular risk in rheumatoid arthritis (RA). Biological disease-modifying antirheumatic drugs (bDMARDs) improve disease activity and cardiovascular disease outcomes. We explored whether bDMARDs influence the impact of disease activity and inflammatory markers on long-term cardiovascular risk in RA.Methods: We studied 4370 participants without cardiovascular disease in a 10-country observational cohort of patients with RA. Endpoints were (1) major adverse cardiovascular events (MACE) encompassing myocardial infarction, stroke and cardiovascular death; and (2) any ischaemic cardiovascular events (iCVE) including MACE plus revascularisation, angina, transient ischaemic attack and peripheral arterial disease.Results: Over 26 534 patient-years, 239 MACE and 362 iCVE occurred. The interaction between 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP) and bDMARD use was significant for MACE (p=0.017), suggesting the effect of DAS28-CRP on MACE risk differed among bDMARD users (n=515) and non-users (n=3855). DAS28-CRP (per unit increase) is associated with MACE risk in bDMARD non-users (HR 1.21 (95% CI 1.07 to 1.37)) but not users (HR 0.69 (95% CI 0.40 to 1.20)). The interaction between CRP (per log unit increase) and bDMARD use was also significant for MACE (p=0.011). CRP associated with MACE risk in bDMARD non-users (HR 1.16 (95% CI 1.04 to 1.30)), but not users (HR 0.65 (95% CI 0.36 to 1.17)). No interaction was observed between bDMARD use and DAS28-CRP (p=0.167) or CRP (p=0.237) for iCVE risk.Conclusions: RA activity and inflammatory markers associated with risk of MACE in bDMARD non-users but not users suggesting the possibility of biological-specific benefits locally on arterial wall independently of effects on systemic inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Arthritis
- Rheumatoid
- Biological Therapy
- Cardiovascular Diseases
- Inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
RMD Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Karpouzas, Georg ...
-
Ormseth, Sarah R ...
-
van Riel, Piet L ...
-
Gonzalez-Gay, Mi ...
-
Corrales, Alfons ...
-
Rantapää-Dahlqvi ...
-
visa fler...
-
Sfikakis, Petros ...
-
Dessein, Patrick
-
Tsang, Linda
-
Hitchon, Carol
-
El-Gabalawy, Han ...
-
Pascual-Ramos, V ...
-
Contreras-Yáñez, ...
-
Colunga-Pedraza, ...
-
Galarza-Delgado, ...
-
Azpiri-Lopez, Jo ...
-
Semb, Anne Grete
-
Misra, Durga Pra ...
-
Hauge, Ellen-Mar ...
-
Kitas, George
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
RMD Open
- Av lärosätet
-
Umeå universitet