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  • Vangeti, Sindhu,1989-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Icahn School of Medicine at Mount Sinai, USA (author)

Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • American Society for Microbiology,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-212584
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-212584URI
  • https://doi.org/10.1128/spectrum.01837-22DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infection. We found a significant decrease of spike IgG and neutralization antibody titers from early (11 to 56 days) to late (4 to 8.5 months) time points postinfection. Over the study period, S1-specific IgG levels declined significantly faster than that of the S2-specific IgG. Further, serum antibodies from PCR-confirmed participants cross-recognized S2, but not S1, of the betacoronaviruses HKU1 and OC43, suggesting a greater degree of cross-reactivity of S2 among betacoronaviruses. Antibody-Dependent Natural Killer cell Activation (ADNKA) was detected at the early time point but significantly decreased at the late time point. Induction of serum Antibody-Dependent Monocyte Phagocytosis (ADMP) was detected in all the infected participants, and its levels remained stable over time. Additionally, a reduced percentage of participants had detectable neutralizing activity against the Beta (50%), Gamma (61 to 67%), and Delta (90 to 94%) variants, both early and late postinfection, compared to the ancestral strain (100%). Antibody binding to S1 and RBD of Beta, Gamma, Delta (1.7 to 2.3-fold decrease), and Omicron (10 to 16-fold decrease) variants was also significantly reduced compared to the ancestral SARS-CoV-2 strain. Overall, we found variable temporal profiles of specific components and functionality of the serological response to SARS-CoV-2 in young adults, which is characterized by lasting, but decreased, neutralizing activity and antibody binding to S1, stable ADMP activity, and relatively stable S2-specific IgG levels.

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  • Periasamy, Sivakumar (author)
  • Sun, Peifang (author)
  • Balinsky, Corey A. (author)
  • Mahajan, Avinash S. (author)
  • Kuzmina, Natalia A. (author)
  • Soares-Schanoski, Alessandra (author)
  • Cooper, Elizabeth (author)
  • Beckett, Charmagne (author)
  • Marayag, Jan (author)
  • Marrone, Amethyst (author)
  • Nunez, Edgar (author)
  • Ge, Yongchao (author)
  • Porter, Chad K. (author)
  • Goforth, Carl W. (author)
  • Lizewski, Stephen E. (author)
  • Lizewski, Rhonda (author)
  • Jani, Vihasi (author)
  • Sugiharto, Victor A. (author)
  • Schilling, Megan (author)
  • Yu, Xuechen B. (author)
  • Marjanovic, Nada (author)
  • George, Mary Catherine (author)
  • Bukreyev, Alexander (author)
  • Sealfon, Stuart C. (author)
  • Letizia, Andrew G. (author)
  • Ramos, Irene (author)
  • Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

Related titles

  • In:Microbiology Spectrum: American Society for Microbiology10:62165-0497

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