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Single-Cell Transcr...
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Mohammed, Mubasher,MscStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-27
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American Society for Microbiology,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-215086
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-215086URI
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https://doi.org/10.1128/spectrum.03671-22DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208221URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512533URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Malaria inflicts the highest rate of morbidity and mortality among the vector-borne diseases. The dramatic bottleneck of parasite numbers that occurs in the gut of the obligatory mosquito vector provides a promising target for novel control strategies. Using single-cell transcriptomics, we analyzed Plasmodium falciparum development in the mosquito gut, from unfertilized female gametes through the first 20 h after blood feeding, including the zygote and ookinete stages. This study revealed the temporal gene expression of the ApiAP2 family of transcription factors and of parasite stress genes in response to the harsh environment of the mosquito midgut. Further, employing structural protein prediction analyses, we found several upregulated genes predicted to encode intrinsically disordered proteins (IDPs), a category of proteins known for their importance in regulation of transcription, translation, and protein-protein interactions. IDPs are known for their antigenic properties and may serve as suitable targets for antibody- or peptide-based transmission suppression strategies. In total, this study uncovers the P. falciparum transcriptome from early to late parasite development in the mosquito midgut, inside its natural vector, which provides an important resource for future malaria transmission-blocking initiatives.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Dziedziech, Alexis,1991-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)aldzi
(author)
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Sekar, VaishnoviStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.(Swepub:su)vase4339
(author)
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Ernest, MedardLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
(author)
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Alves E Silva, Thiago LuizLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
(author)
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Balan, BaluPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
(author)
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Emami, S. NoushinStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)nemam
(author)
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Biryukova, InnaStockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.(Swepub:su)einna
(author)
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Friedländer, Marc R.Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.(Swepub:su)mfrie
(author)
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Jex, AaronPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
(author)
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Jacobs-Lorena, MarceloDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States,Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
(author)
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Henriksson, JohanUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Univ, Dept Mol Biol, Lab Mol Infect Med Sweden MIMS, Umeå, Sweden.(Swepub:umu)johe6219
(author)
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Vega-Rodriguez, JoelLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
(author)
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Ankarklev, JohanUppsala universitet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; Microbial Single Cell Genomics, Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Science for Life Laboratory, SciLifeLab,Molekylär evolution,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden(Swepub:uu)joank425
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Microbiology Spectrum: American Society for Microbiology11:22165-0497
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