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Social Health and C...
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Marseglia, AnnaKarolinska Institutet
(författare)
Social Health and Cognitive Change in Old Age : Role of Brain Reserve
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2023-01-18
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John Wiley & Sons,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-215286
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-215286URI
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https://doi.org/10.1002/ana.26591DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151778598URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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SNAC-K (http://www.snac.org) is financially supported by the Swedish Ministry of Health and Social Affairs; participating county councils and municipalities; the Swedish Research Council; and the Swedish Research Council for Health, Working Life, and Welfare. This project is part of the SHARED Consortium (https://www.shared-dementia.eu/), an EU Joint Program–Neurodegenerative Disease Research (JPND; www.jpnd.eu) project (grant no. 733051082). A.M. and A.-K.W. lead the Swedish stream of the SHARED Consortium and are funded by the Swedish Research Council for Health, Working Life, and Welfare (FORTE grant no. 2018-01888). J.M. and P.P. are part of the UK-led stream of the JPND consortium and are funded by the Alzheimer's Society (grant no. 469) in the UK. S.D. acknowledges support from the Swedish Research Council for Health, Working Life, and Welfare (FORTE grant no. 2019-01076).
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Objective: Individual aspects of social health (SH; eg, network, engagement, support) have been linked to cognitive health. However, their combined effect and the role of the structural properties of the brain (brain reserve [BR]) remain unclear. We investigated the interplay of SH and BR on cognitive change in older adults.Methods: Within the Swedish National Study on Aging and Care–Kungsholmen, 368 dementia-free adults aged ≥60 years with baseline brain magnetic resonance imaging were followed over 12 years to assess cognitive change. A measure of global cognition was computed at each of the 5 waves of assessment by averaging domain-specific Z scores for episodic memory, perceptual speed, semantic memory, and letter and category fluency. An SH composite score was computed at baseline by combining leisure activities and social network. BR was proxied by total brain tissue volume (TBTV). Linear mixed models (adjusted for sociodemographic, vascular, and genetic factors) were used to estimate cognitive trajectories in relation to SH and TBTV. Interaction analysis and stratification were used to examine the interplay between SH and TBTV.Results: Moderate–good SH (n = 245; vs poor, β-slope = 0.01, 95% confidence interval [CI] = 0.002–0.02, p = 0.018) and moderate-to-large TBTV (n = 245; vs small, β-slope = 0.03, 95% CI = 0.02–0.04, p < 0.001) were separately associated with slower cognitive decline. In stratified analysis, moderate–good SH was associated with higher cognitive levels (but not change) only in participants with moderate-to-large TBTV (β-intercept = 0.21, 95% CI = 0.06–0.37, p < 0.01; interaction SH * TBTV, p < 0.05).Interpretation: Our findings highlight the interplay between SH and BR that likely unfolds throughout the entire life course to shape old-age cognitive outcomes. ANN NEUROL 2023
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kalpouzos, GrégoriaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(författare)
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Laukka, Erika J.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Stockholm, Sweden
(författare)
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Maddock, Jane
(författare)
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Patalay, Praveetha
(författare)
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Wang, Hui-XinStockholms universitet,Stressforskningsinstitutet,Biologisk psykologi(Swepub:su)huiwa
(författare)
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Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(författare)
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Westman, EricKarolinska Institutet
(författare)
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Welmer, Anna-KarinKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Stockolm, Sweden; Karolinska University Hospital, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden
(författare)
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Dekhtyar, SerhiyKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)(Swepub:su)sdekh
(författare)
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Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of Neurology: John Wiley & Sons93:4, s. 844-8550364-51341531-8249
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Marseglia, Anna
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Kalpouzos, Grégo ...
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Laukka, Erika J.
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Maddock, Jane
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Patalay, Praveet ...
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Wang, Hui-Xin
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Bäckman, Lars
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Westman, Eric
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