Association of lifespan reproductive duration with depression in Swedish twins: The role of hormone replacement therapy

Association of lifespan reproductive duration with depression in Swedish twins : The role of hormone replacement therapy

Objective: To examine the association between reproductive duration and postmenopausal depression (taking the use of hormone replacement therapy [HRT] into account).Methods: In this population-based cohort study, 11 320 postmenopausal women (mean age 63.6 years) were followed for up to 18 years. Reproductive duration was categorized into three groups: short (≤34 years), average (35–39 years), and long (≥40 years). Depression was ascertained from the Sweden National Patient Registry.Results: During the follow up, 593 (5.24%) women developed depression. In the multi-adjusted generalized estimating equation model, the odds ratios (ORs) of depression were 1.28 (95% confidence interval [CI] 1.05–1.55) and 1.25 (95% CI 1.01–1.55) for women with short and long reproductive durations, respectively, compared with those women with average reproductive duration. Women with a non-typical reproductive duration (≤34 or ≥40 years) who received HRT were at a higher risk of depression (OR 1.82, 95% CI 1.42–2.33). There was a significant additive interaction between non-typical reproductive duration and the use of HRT on depression (attributable proportion 0.26, 95% CI 0.03–0.50).Conclusion: Women with a short or long reproductive duration, especially those with a history of HRT use, have a higher risk of depression after menopause compared with those with an average reproductive duration.

Yang, Wenzhe (författare)
Li, Xuerui (författare)
Wang, Zhiyu (författare)
Zhang, Lulu (författare)
Wang, Jiao (författare)
Qi, Xiuying (författare)
Dove, AbigailKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (författare)
Xu, WeiliKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China; Tianjin Key Laboratory of Environment, Nutrition, and Public Health, China; Tianjin Center for International Collaborative Research in Environment, Nutrition and Public Health, China (författare)
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Ingår i:International Journal of Gynecology & Obstetrics: Wiley162:1, s. 309-3160020-72921879-3479

Av författaren/redakt...: Wang, Shuqi; Yang, Wenzhe; Li, Xuerui; Wang, Zhiyu; Zhang, Lulu; Wang, Jiao; visa fler...; Qi, Xiuying; Dove, Abigail; Xu, Weili; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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