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  • Alexandersson, Bjarki T.Karolinska Inst, Dept Med Solna, Stockholm, Sweden. (författare)

Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis : a population-based colonoscopy study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-03-29
  • Informa UK Limited,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-216969
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-216969URI
  • https://doi.org/10.1080/00365521.2023.2194010DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152423092URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519804URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This work was Supported by grants provided by the Stockholm County Council (ALF project, grant number FoUI-953903), Signe och Olof Wallenius Stiftelse, Rut och Richard Julin’s Foundation (grant number 2020-00282), Stiftelsen Professor Nanna Svartz Foundation (grant number 2020-00358), and the Ragnar Söderbergs Stiftelse Foundation.
  • Background: The etiopathogenesis of diverticular disease is unknown.Objective: To compare the fecal and mucosa-associated microbiota between participants with and without diverticulosis and participants who later developed diverticulitis versus those that did not from a population-based study.Methods: The PopCol study, conducted in Stockholm, Sweden, invited a random sample of 3556 adults to participate, of which 745 underwent colonoscopy. Overall, 130 participants (17.5%) had diverticulosis. 16S rRNA gene sequencing was conducted on available sigmoid biopsy samples from 529 and fecal samples from 251 individuals. We identified individuals who subsequently developed acute diverticulitis up to 13 years after sample collection. In a case-control design matching for gender, age (+/−5 years), smoking and antibiotic exposure, we compared taxonomic composition, richness and diversity of the microbiota between participants with or without diverticulosis, and between participants who later developed acute diverticulitis versus those who did not.Results: No differences in microbiota richness or diversity were observed between participants with or without diverticulosis, nor for those who developed diverticulitis compared with those who did not. No bacterial taxa were significantly different between participants with diverticulosis compared with those without diverticulosis. Individuals who later developed acute diverticulitis (2.8%) had a higher abundance of genus Comamonas than those who did not (p = .027).Conclusions: In a population-based cohort study the only significant difference was that those who later develop diverticulitis had more abundance of genus Comamonas. The significance of Comamonas is unclear, suggesting a limited role for the gut microbiota in the etiopathogenesis of diverticular disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hugerth, Luisa W.Karolinska Institutet,Karolinska Inst, Tumour & Cell Biol MTC, Dept Microbiol, Sci Life Lab,CTMR, Solna, Sweden. (författare)
  • Hedin, CharlotteKarolinska Institutet,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden. (författare)
  • Forsberg, AnnaKarolinska Inst, Dept Med Solna, Stockholm, Sweden. (författare)
  • Talley, Nicholas J.Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia. (författare)
  • Agreus, LarsKarolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden. (författare)
  • Järbrink-Sehgal, EllionoreKarolinska Inst, Dept Med Solna, Stockholm, Sweden.;Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX USA. (författare)
  • Engstrand, LarsKarolinska Inst, Tumour & Cell Biol MTC, Dept Microbiol, Sci Life Lab,CTMR, Solna, Sweden. (författare)
  • Andreasson, Anna,1980-Stockholms universitet,Stressforskningsinstitutet,Biologisk psykologi,Karolinska Institutet, Sweden; Macquarie University, Australia,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, Stockholm, Sweden.;Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia.(Swepub:su)anan6088 (författare)
  • Schmidt, Peter T.Uppsala universitet,Gastroenterologi/hepatologi,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.(Swepub:uu)petth375 (författare)
  • Karolinska InstitutetKarolinska Inst, Dept Med Solna, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scandinavian Journal of Gastroenterology: Informa UK Limited58:10, s. 1131-11380036-55211502-7708

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