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  • Balter, Leonie J. T.Stockholms universitet,Stressforskningsinstitutet,Biologisk psykologi,Karolinska Institutet, Sweden (författare)

Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-217359
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-217359URI
  • https://doi.org/10.1016/j.psyneuen.2023.106110DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152533004URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This work was supported by Swedish Research Council Grants to MJO [2012-1125 and 2016-02742].
  • Metabolites of the kynurenine pathway are hypothesized to be implicated in inflammation-associated depression, but there is a lack of experimental studies in humans assessing the kinetics of kynurenine metabolites in relation to experimentally-induced sickness. The aim of the present study was to assess changes in the kynurenine pathway and to explore its relation to symptoms of sickness behavior during an acute experimental immune challenge.This double-blind placebo-controlled randomized cross-over study included 22 healthy human participants (n = 21 both sessions, Mage = 23.4, SD = 3.6, nine women) who received an intravenous injection of 2.0 ng/kg lipopolysaccharide (LPS) and saline (placebo) on two different occasions in a randomized order. Blood samples (0 h, 1 h, 1.5 h, 2 h, 3 h, 4 h, 5 h, 7 h post-injection) were analyzed for kynurenine metabolites and inflammatory cytokines. The intensity of symptoms of sickness behavior was assessed using the 10-item Sickness Questionnaire at 0 h, 1.5 h, 3 h, 5 h, and 7 h post-injection.LPS induced significantly lower concentrations of plasma tryptophan (at 2 h, 4 h, 5 h, and 7 h post-injection), kynurenine (at 2 h, 3 h, 4 h, and 5 h post-injection), nicotinamide (at 4 h, 5 h, and 7 h post-injection), and higher levels for quinolinic acid at 5 h post-injection as compared to placebo. LPS did not affect kynurenic acid, 3-hydroxykynurenine, and picolinic acid. The development of the sickness symptoms was largely similar across items, with the highest levels around 1.5–3 h post-injection. Changes in plasma levels of kynurenine metabolites seem to coincide rather than precede or follow changes in subjective sickness. Exploratory analyses indicate that higher Sickness Questionnaire total scores at 1.5–5 h post-injection were correlated with lower kynurenic acid and nicotinamide levels.These results lend further support for LPS-induced changes in the kynurenine pathway, but may not, as interpreted from blood levels, causally link to LPS-induced acute symptoms of sickness behavior. Future research may consider a larger sample to further scrutinize the role of the kynurenine pathway in the sickness response.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, Xueqi (författare)
  • Schwieler, LillyKarolinska Institutet (författare)
  • Erhardt, SophieKarolinska Institutet (författare)
  • Axelsson, JohnStockholms universitet,Stressforskningsinstitutet,Biologisk psykologi,Karolinska Institutet, Sweden(Swepub:su)jaxel (författare)
  • Olsson, Mats J.Karolinska Institutet (författare)
  • Lasselin, JulieStockholms universitet,Stressforskningsinstitutet,Biologisk psykologi,Karolinska Institutet, Sweden(Swepub:su)jlass (författare)
  • Lekander, Mats,1959-Stockholms universitet,Stressforskningsinstitutet,Biologisk psykologi,Karolinska Institutet, Sweden(Swepub:su)mleka (författare)
  • Stockholms universitetStressforskningsinstitutet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Psychoneuroendocrinology1530306-45301873-3360

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