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  • Tuleasca, Constantin (author)

The Relevance of Biologically Effective Dose for Hearing Preservation After Stereotactic Radiosurgery for Vestibular Schwannomas : A Retrospective Longitudinal Study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:su-219185
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-219185URI
  • https://doi.org/10.1227/neu.0000000000002352DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495242URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152783967URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De tre sista författarna delar sistaförfattarskapet
  • BACKGROUND: Stereotactic radiosurgery has become a common treatment approach for small-to-medium size vestibular schwannomas.OBJECTIVE: To evaluate relationship between time (beam-on and treatment) and risk of hearing decline after stereotactic radiosurgery for vestibular schwannomas in patients with Gardner–Robertson (GR) baseline classes I and II.METHODS: This retrospective longitudinal single-center study included 213 patients with GR I and II treated between June 2010 and December 2019. Risk of passing from GR classes I and II (coded 0) to other classes III, IV, and V (coded 1) and the increase in pure tone average (continuous outcome) were evaluated using a mixed-effect regression model. Biologically effective dose (BED) was further assessed for an alpha/beta ratio of 2.47 (Gy2.47).RESULTS: Binary outcome analysis revealed sex, dose rate, integral dose, time [beam-on time odds ratio 1.03, P = .03, 95% CI 1.00-1.06; treatment time (P = .02) and BED (P = .001) as relevant. Fitted multivariable model included the sex, dose rate, and BED. Pure tone average analysis revealed age, integral dose received by tumor, isocenter number, time (beam-on time odds ratio 0.20, P = .001, 95% CI 0.083-0.33) and BED (P = .005) as relevant.CONCLUSION: Our analysis showed that risk of hearing decline was associated with male sex, higher radiation dose rate (cutoff 2.5 Gy/minute), higher integral dose received by the tumor, higher beam-on time ≥20 minutes, and lower BED. A BED between 55 and 61 was considered as optimal for hearing preservation. 

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  • Toma-Daşu, Iuliana,1972-Karolinska Institutet,Stockholms universitet,Fysikum(Swepub:su)iuda0736 (author)
  • Duroux, Sebastien (author)
  • Starnoni, Daniele (author)
  • George, Mercy (author)
  • Maire, Raphael (author)
  • Daniel, Roy Thomas (author)
  • Patin, David (author)
  • Schiappacasse, Luis (author)
  • Dasu, Alexandru,1972-Uppsala universitet,Institutionen för immunologi, genetik och patologi,The Skandion Clinic, Uppsala, Sweden,Medicinsk fysik/Skandionkliniken(Swepub:uu)aleda511 (author)
  • Faouzi, Mohamed (author)
  • Levivier, Marc (author)
  • Stockholms universitetFysikum (creator_code:org_t)

Related titles

  • In:Neurosurgery: Ovid Technologies (Wolters Kluwer Health)92:6, s. 1216-12260148-396X1524-4040

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