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In Vitro Antimicrob...
In Vitro Antimicrobial and Antibiofilm Properties and Bioaccessibility after Oral Digestion of Chemically Characterized Extracts Obtained from Cistus × incanus L., Scutellaria lateriflora L., and Their Combination
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- Ullah, Hammad (author)
- Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.
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- Di Minno, Alessandro (author)
- Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.;CEINGE BiotecnologieAvanzate, Via Gaetano Salvatore 486, I-80145 Naples, NA, Italy.
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- Di Filippis, Anna (author)
- Univ Campania L Vanvitelli, Dept Expt Med, Sect Microbiol & Clin Microbiol, Via Crecchio 7, I-80138 Naples, NA, Italy.
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- Sommella, Eduardo (author)
- Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy.
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- Buccato, Daniele Giuseppe (author)
- Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.
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- De Lellis, Lorenza Francesca (author)
- Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.
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- El-Seedi, Hesham (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Khalifa, Shaden A. M., 1974- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
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- Piccinocchi, Roberto (author)
- AUO Luigi Vanvitelli, Level 1 Med Director Anaesthesia & Resuscitat, Via St Maria Costantinopoli, I-80138 Naples, NA, Italy.
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- Galdiero, Massimiliano (author)
- Univ Campania L Vanvitelli, Dept Expt Med, Sect Microbiol & Clin Microbiol, Via Crecchio 7, I-80138 Naples, NA, Italy.;Univ Hosp Campania Luigi Vanvitelli, UOC Virol & Microbiol, I-80138 Naples, NA, Italy.
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- Campiglia, Pietro (author)
- Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy.;European Biomed Res Inst Salerno, Via Renzi 50, I-84125 Salerno, SA, Italy.
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- Daglia, Maria (author)
- Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
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Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, NA, Italy.;CEINGE BiotecnologieAvanzate, Via Gaetano Salvatore 486, I-80145 Naples, NA, Italy. (creator_code:org_t)
- MDPI, 2023
- 2023
- English.
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In: Foods. - : MDPI. - 2304-8158. ; 12:9
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Periodontal diseases are oral inflammatory diseases ranging from gingivitis to chronic periodontitis. Porphyromonas gingivalis is one of the major pathogens responsible for severe and chronic periodontitis. Plant extracts with antimicrobial activity could be considered possible alternatives to chlorhexidine, an antiseptic substance used in oral hygiene thatcan cause bacteria resistance. Here, two commercial extracts obtained from Cistus × incanus L. and Scutellaria lateriflora L. were chemically characterized usingUltra-High-Performance Liquid Chromatography (UHPLC) coupled with a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer. The extracts were studied for their bioaccessibility after simulated in vitro oral digestion, their antimicrobial activity against P. gingivalis, their protective effects against cellular invasion by P. gingivalis, and their antibiofilm activity. The extracts were found to contain very complex mixtures of polyphenols, which were quite stable after in vitro simulated oral digestion and demonstrated mild, dose-dependent inhibitory activity against P. gingivalis growth. This activity increased with the combination of the two extracts. Moreover, the combination of the extracts induced a reduction in P. gingivalis HaCaT invasiveness, and the reduction in biofilm came to around 80%. In conclusion, a combination of C. incanus and S. lateriflora showed promising effects useful in the treatment of gingivitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Cistus x incanus L.
- Scutellaria lateriflora L.
- oral health
- gingivitis
- Porphyromonas gingivalis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ullah, Hammad
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Di Minno, Alessa ...
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Di Filippis, Ann ...
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Sommella, Eduard ...
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Buccato, Daniele ...
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De Lellis, Loren ...
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El-Seedi, Hesham
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Khalifa, Shaden ...
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Piccinocchi, Rob ...
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Galdiero, Massim ...
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Campiglia, Pietr ...
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Daglia, Maria
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Dentistry
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Foods
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Stockholm University
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Uppsala University