Search: L773:1742 4933
> (2020-2023) >
Objectively-measure...
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults : a population-based study
-
- Wang, Yongxiang (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, Jinan, People’s Republic of China
-
Han, Qi (author)
-
Han, Xiaolei (author)
-
show more...
-
Dong, Yi (author)
-
Mao, Ming (author)
-
Wang, Chaoqun (author)
-
Wang, Xiaojie (author)
-
Tang, Shi (author)
-
- Liu, Cuicui (author)
- Karolinska Institutet
-
- Li, Yuanjing (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
-
Hou, Tingting (author)
-
Cong, Lin (author)
-
Du, Yifeng (author)
-
- Qiu, Chengxuan (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, People’s Republic of China
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Immunity & Ageing. - 1742-4933. ; 20:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BackgroundEvidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, the underlying mechanisms are poorly understood. We examined the associations of the accelerometer-measured movement behaviors with plasma neurofilament light chain (NfL) among older adults and the role of systemic low-grade inflammation in the associations.ResultsThis population-based study included 1,029 dementia-free older adults (age & GE; 60 years, range 60-88 years; 59.48% women) who undertook the ActiGraph substudy (March 2018-December 2020) in MIND-China. There were nonlinear relationships of daily SB and PA time with plasma NfL concentration, such that more daily SB time or less time spent in daily light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was significantly associated with increased plasma NfL only when SB time & GE; 8.00 h/day or LPA time < 5.00 h/day or MVPA time < 2.00 h/day. Furthermore, more daily SB time or less daily LPA and MVPA time was significantly associated with higher serum low-grade inflammation score, a composite measure generated from serum IL-6, IL-8, TNF-& alpha;, and ICAM-1 (P < 0.05). Finally, low-grade inflammation score accounted for 14.5% to 17.8% of the associations between movement behaviors and plasma NfL.ConclusionsMore daily SB and less PA time are associated with neurodegeneration and systemic low-grade inflammation in older adults. The association of movement behaviors with neurodegeneration is partially mediated by low-grade inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Accelerometer
- Movement behaviors
- Neurofilament light chain
- Low-grade inflammation
- Population-based study
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wang, Yongxiang
-
Han, Qi
-
Han, Xiaolei
-
Dong, Yi
-
Mao, Ming
-
Wang, Chaoqun
-
show more...
-
Wang, Xiaojie
-
Tang, Shi
-
Liu, Cuicui
-
Li, Yuanjing
-
Hou, Tingting
-
Cong, Lin
-
Du, Yifeng
-
Qiu, Chengxuan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
- Articles in the publication
-
Immunity & Agein ...
- By the university
-
Stockholm University
-
Karolinska Institutet