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Self-reported sleep...
Self-reported sleep characteristics associated with dementia among rural-dwelling Chinese older adults : a population-based study
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Liu, Rui (författare)
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Tang, Shi (författare)
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Wang, Yongxiang (författare)
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Dong, Yi (författare)
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Hou, Tingting (författare)
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Ren, Yifei (författare)
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Cong, Lin (författare)
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Liu, Keke (författare)
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Qin, Yu (författare)
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- Sindi, Shireen (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Imperial College London, UK
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Du, Yifeng (författare)
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- Qiu, Chengxuan (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, People’s Republic of China; Shandong First Medical University, People’s Republic of China
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(creator_code:org_t)
- 2022-01-03
- 2022
- Engelska.
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Ingår i: BMC Neurology. - : Springer Science and Business Media LLC. - 1471-2377. ; 22
- Relaterad länk:
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https://doi.org/10.1...
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https://bmcneurol.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Sleep characteristics associated with dementia are poorly defined and whether their associations vary by demographics and APOE genotype among older adults are unclear.Methods: This population-based cross-sectional study included 4742 participants (age ≥ 65 years, 57.1% women) living in rural China. Sleep parameters were measured using the self-rated questionnaires of the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria, and the National Institute on Aging-Alzheimer’s Association criteria for Alzheimer’s disease (AD). Data were analysed using multiple logistic and general linear regression models.Results: Dementia was diagnosed in 173 participants (115 with AD). Multivariable-adjusted odds ratio (OR) of dementia was 1.71 (95%CI, 1.07-2.72) for sleep duration ≤4 h/night (vs. > 6-8 h/night), 0.76 (0.49-1.18) for > 4-6 h/night, 1.63 (1.05-2.55) for > 8 h/night, 1.11 (1.03-1.20) for lower sleep efficiency (per 10% decrease), and 1.85 (1.19-2.89) for excessive daytime sleepiness. Very short sleep duration (≤4 h/night), lower sleep efficiency, and excessive daytime sleepiness were significantly associated with being diagnosed with AD (multivariable-adjusted OR range = 1.12-2.07; p < 0.05). The associations of sleep problems with dementia and AD were evident mainly among young-old adults (65-74 years) or APOE ε4 carriers. Among dementia-free participants, these sleep characteristics were significantly associated with a lower MMSE score.Conclusions: Self-reported sleep problems in dementia are characterized by very short or long sleep duration, low sleep efficiency, and excessive daytime sleepiness, especially among young-old people and APOE ε4 carriers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Older adults
- Sleep
- Cognitive function
- Dementia
- Alzheimer's disease
- Population-based study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liu, Rui
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Tang, Shi
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Wang, Yongxiang
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Dong, Yi
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Hou, Tingting
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Ren, Yifei
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visa fler...
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Cong, Lin
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Liu, Keke
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Qin, Yu
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Sindi, Shireen
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Du, Yifeng
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Qiu, Chengxuan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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BMC Neurology
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet