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White matter abnorm...
White matter abnormalities mediate the association between masticatory dysfunction and cognition among older adults
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- Hedberg, Linn (författare)
- Folktandvården Eastmaninstitutet, Stockholm, Sweden; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; Academic Centre for Geriatric Dentistry, Stockholm, Sweden
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- Kumar, Abhishek (författare)
- Karolinska Institutet
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- Skott, Pia (författare)
- Folktandvården Eastmaninstitutet, Stockholm, Sweden; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; Academic Centre for Geriatric Dentistry, Stockholm, Sweden
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- Smedberg, Jan-Ivan (författare)
- Folktandvården Eastmaninstitutet, Stockholm, Sweden; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Seiger, Ake (författare)
- Academic Centre for Geriatric Dentistry, Stockholm, Sweden; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden
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- Sandborgh-Englund, Gunilla (författare)
- Karolinska Institutet
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- Nordin, Love Engstrom (författare)
- Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Department of Diagnostic Medical Physics, Karolinska University Hospital, Stockholm, Sweden
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- Kåreholt, Ingemar, 1960- (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Jönköping University, Sweden,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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- Tzortzakakis, Antonios (författare)
- Karolinska Institutet
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- Westman, Eric (författare)
- Karolinska Institutet
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- Trulsson, Mats (författare)
- Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; Academic Centre for Geriatric Dentistry, Stockholm, Sweden
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- Ekman, Urban (författare)
- Karolinska Institutet
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842. ; 50:12, s. 1422-1431
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Masticatory parameters, such as reduced number of teeth and posterior contacts, have been shown to be associated with reduced cognitive status. The underlying mechanisms that affect these associations, are however, not well understood. Objectives: The study aims to investigate the association between masticatory dysfunction and cognition and explore the mediating effect of brain structure. Methods: In this cross-sectional study, 45 older adults with subjective masticatory dysfunction (mean age 72.3 +/- 4.0 years) were included. Mini-Mental State Examination score <25, brain trauma, neurological disease, neurodegenerative disorders, depression or poor Swedish language skills were criteria for exclusion. Cognitive functions (executive function and episodic memory) and masticatory dysfunction defined by functional occluding status (FOS; the number of occluding units and number of remaining teeth) were analysed with partial correlation models. Structural magnetic resonance imaging was performed on 28 feasible participants. Multiple regression analyses were performed to evaluate the predictive value of brain structure and white matter hypointensities (WM-hypo) on cognitive functions. A mediation analysis was applied to assess significant predictor/s of the association between FOS and cognition. Results: Both episodic memory and executive functions were positively correlated with FOS. WM-hypo predicted cognitive status (executive function, p = .01). WM-hypo mediated 66.6% (p = 0.06) of the association between FOS and executive functions. Conclusion: Associations between FOS and cognitive functions are reported, where FOS, a potential modifiable risk factor, was related to both episodic memory and executive functions. The mediating effect of WM-hypo on the association between FOS and executive functions highlights the impact of the vascularisation of the brain on the link between mastication and cognition. The present study provides increased knowledge that bridges the gap between masticatory dysfunction and cognition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- cognitive aging
- cognitive function
- magnetic resonance imaging
- mastication
- masticatory function
- vascular injuries
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hedberg, Linn
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Kumar, Abhishek
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Skott, Pia
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Smedberg, Jan-Iv ...
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Seiger, Ake
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Sandborgh-Englun ...
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visa fler...
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Nordin, Love Eng ...
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Kåreholt, Ingema ...
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Tzortzakakis, An ...
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Westman, Eric
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Trulsson, Mats
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Ekman, Urban
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Oral ...
- Av lärosätet
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Stockholms universitet
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Jönköping University
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Karolinska Institutet