Sökning: WFRF:(Sandanger Torkjel M.)
> (2023) >
Fluorine Mass Balan...
Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015
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Cioni, Lara (författare)
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- Plassmann, Merle, 1981- (författare)
- Stockholms universitet,Institutionen för miljövetenskap
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- Benskin, Jonathan P., 1981- (författare)
- Stockholms universitet,Institutionen för miljövetenskap
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Coêlho, Ana Carolina M. F. (författare)
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Nøst, Therese H. (författare)
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Rylander, Charlotta (författare)
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Nikiforov, Vladimir (författare)
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Sandanger, Torkjel M. (författare)
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Herzke, Dorte (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Environmental Science and Technology. - 0013-936X .- 1520-5851. ; 57:40, s. 14849-14860
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Of the thousands of per- and polyfluoroalkyl substances (PFAS) known to exist, only a small fraction (≤1%) are commonly monitored in humans. This discrepancy has led to concerns that human exposure may be underestimated. Here, we address this problem by applying a comprehensive fluorine mass balance (FMB) approach, including total fluorine (TF), extractable organic fluorine (EOF), total oxidizable precursors (TOP), and selected target PFAS, to human serum samples collected over a period of 28 years (1986, 2007, and 2015) in Tromsø, Norway. While concentrations of TF did not change between sampling years, EOF was significantly higher in 1986 compared to 2007 and 2015. The ∑12PFAS concentrations were highest in 2007 compared to 1986 and 2015, and unidentified EOF (UEOF) decreased from 1986 (46%) to 2007 (10%) and then increased in 2015 (37%). While TF and EOF were not influenced by sex, women had higher UEOF compared to men, opposite to target PFAS. This is the first FMB in human serum to include TOP, and it suggests that precursors with >4 perfluorinated carbon atoms make a minor contribution to EOF (0–4%). Additional tools are therefore needed to identify substances contributing to the UEOF in human serum.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- human exposure
- PFAS
- PFAA precursors
- TF
- EOF
- TOP assay
- time trend
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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