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Multimorbidity, cog...
Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults : A population-based study
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Ren, Yifei (author)
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- Li, Yuanjing (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Tian, Na (author)
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Liu, Rui (author)
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Dong, Yi (author)
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Hou, Tingting (author)
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- Liu, Cuicui (author)
- Karolinska Institutet
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Han, Xiaolei (author)
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Han, Xiaodong (author)
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Wang, Lidan (author)
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- Vetrano, Davide Liborio (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
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Ngandu, Tiia (author)
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- Marengoni, Alessandra (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Brescia, Italy
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- Kivipelto, Miia (author)
- Karolinska Institutet
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- Wang, Yongxiang (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, P. R. China; Shandong First Medical University, P. R. China; Shandong Provincial Clinical Research Center for Geriatric Neurological Diseases, P. R. China; Shandong Academy of Medical Sciences, China
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Cong, Lin (author)
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Du, Yifeng (author)
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- Qiu, Chengxuan (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, P. R. China; Shandong First Medical University, P. R. China; Shandong Academy of Medical Sciences, China
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1550-1561
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- INTRODUCTION: To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults.METHODS: This population-based study included 5432 participants (age ≥60 years); of these, plasma amyloid beta (Aβ), total tau, and neurofilament light chain (NfL) were measured in a subsample (n = 1412). We used hierarchical clustering to generate five multimorbidity clusters from 23 chronic diseases. We diagnosed dementia and MCI following international criteria. Data were analyzed using logistic and linear regression models.RESULTS: The number of chronic diseases was associated with dementia (multivariable-adjusted odds ratio = 1.22; 95% confidence interval [CI] = 1.11 to 1.33), AD (1.13; 1.01 to 1.26), vascular dementia (VaD) (1.44; 1.25 to 1.64), and non-amnestic MCI (1.25; 1.13 to 1.37). Metabolic cluster was associated with VaD and non-amnestic MCI, whereas degenerative ocular cluster was associated with AD (p < 0.05). The number of chronic diseases was associated with increased plasma Aβ and NfL (p < 0.05).DISCUSSION: Multimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD-related plasma biomarkers in older adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- dementia
- mild cognitive impairment
- multimorbidity
- plasma biomarkers
- population-based study
- rural
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ren, Yifei
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Li, Yuanjing
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Tian, Na
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Liu, Rui
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Dong, Yi
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Hou, Tingting
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show more...
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Liu, Cuicui
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Han, Xiaolei
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Han, Xiaodong
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Wang, Lidan
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Vetrano, Davide ...
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Ngandu, Tiia
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Marengoni, Aless ...
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Kivipelto, Miia
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Wang, Yongxiang
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Cong, Lin
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Du, Yifeng
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Qiu, Chengxuan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Stockholm University
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Karolinska Institutet