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  • Omnus, Deike J.,1981-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Uppsala University, Sweden,Stockholm Univ, Wenner Gren Inst, Sci Life Lab, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrhenius vag 20C, S-10691 Stockholm, Sweden. (author)

The heat shock protein LarA activates the Lon protease in response to proteotoxic stress

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Springer Nature,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-225405
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-225405URI
  • https://doi.org/10.1038/s41467-023-43385-xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521199URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154558514URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The Lon protease is a highly conserved protein degradation machine that has critical regulatory and protein quality control functions in cells from the three domains of life. Here, we report the discovery of a α-proteobacterial heat shock protein, LarA, that functions as a dedicated Lon regulator. We show that LarA accumulates at the onset of proteotoxic stress and allosterically activates Lon-catalysed degradation of a large group of substrates through a five amino acid sequence at its C-terminus. Further, we find that high levels of LarA cause growth inhibition in a Lon-dependent manner and that Lon-mediated degradation of LarA itself ensures low LarA levels in the absence of stress. We suggest that the temporal LarA-dependent activation of Lon helps to meet an increased proteolysis demand in response to protein unfolding stress. Our study defines a regulatory interaction of a conserved protease with a heat shock protein, serving as a paradigm of how protease activity can be tuned under changing environmental conditions.

Subject headings and genre

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  • Fink, Matthias J.,1988-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Uppsala University, Sweden,Stockholm Univ, Wenner Gren Inst, Sci Life Lab, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrhenius vag 20C, S-10691 Stockholm, Sweden.(Swepub:su)mafi3766 (author)
  • Kallazhi, Aswathy,1992-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Wenner Gren Inst, Sci Life Lab, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrhenius vag 20C, S-10691 Stockholm, Sweden.(Swepub:su)aska9912 (author)
  • Xandri Zaragoza, MariaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Wenner Gren Inst, Sci Life Lab, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrhenius vag 20C, S-10691 Stockholm, Sweden. (author)
  • Leppert, AxelKarolinska Inst, Dept Microbiol Tumor & Cell Biol, Solnavagen 9, S-17165 Solna, Sweden. (author)
  • Landreh, MichaelUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solnavagen 9, S-17165 Solna, Sweden.(Swepub:uu)micla833 (author)
  • Jonas, Kristina,1980-Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Sci Life Lab, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrhenius vag 20C, S-10691 Stockholm, Sweden.(Swepub:su)krijo (author)
  • Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Nature142041-1723

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