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  • Kvedaraite, EgleCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden (author)

Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Springer Nature,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-228132
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-228132URI
  • https://doi.org/10.1038/s41467-024-46076-3DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344195URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238409190URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155279549URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20240307
  • Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142−/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142−/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lourda, MagdaKarolinska Institutet (author)
  • Mouratidou, Natalia (author)
  • Düking, Tim (author)
  • Padhi, Avinash (author)
  • Moll, Kirsten (author)
  • Czarnewski, Paulo,1991-Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)pacz1456 (author)
  • Sinha, Indranil (author)
  • Xagoraris, IoannaKarolinska Institutet (author)
  • Kokkinou, Efthymia (author)
  • Damdimopoulos, Anastasios (author)
  • Weigel, Whitney (author)
  • Hartwig, Olga (author)
  • Santos, Telma E. (author)
  • Soini, Tea (author)
  • Van Acker, Aline (author)
  • Rahkonen, Nelly (author)
  • Flodström Tullberg, Malin (author)
  • Ringqvist, Emma (author)
  • Buggert, Marcus (author)
  • Jorns, Carl (author)
  • Lindforss, Ulrik (author)
  • Nordenvall, CarolineKarolinska Institutet (author)
  • Stamper, Christopher T. (author)
  • Jess, David UnnersjöKTH,Biofysik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u10c8quf (author)
  • Akber, Mira (author)
  • Nadisauskaite, Ruta (author)
  • Jansson, Jessica (author)
  • Vandamme, Niels (author)
  • Sorini, Chiara (author)
  • Grundeken, Marijke Elise (author)
  • Rolandsdotter, Helena (author)
  • Rassidakis, GeorgeKarolinska Institutet (author)
  • Villablanca, Eduardo J. (author)
  • Ideström, Maja (author)
  • Eulitz, Stefan (author)
  • Arnell, Henrik (author)
  • Mjösberg, Jenny (author)
  • Henter, Jan-Inge (author)
  • Svensson, MattiasCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (author)
  • Karolinska InstitutetCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Nature15:12041-1723

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