Search: (WFRF:(Guéant Rodriguez Rosa Maria)) >
Diagnosis, Treatmen...
Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults : A Delphi Expert Consensus
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-229299
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-229299URI
-
https://doi.org/10.3390/jcm13082176DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:157721789URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Andrès, Emmanuel
(author)
-
Češka, Richard
(author)
-
Hooshmand, BabakKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Benedictus Klinikum Tutzing, Germany; Ludwig Maximillian University Hospital, Germany
(author)
-
Guéant-Rodriguez, Rosa-Maria
(author)
-
Prada, Gabriel Ioan
(author)
-
Sławek, Jarosław
(author)
-
Traykov, Latchezar
(author)
-
Van, Binh Ta
(author)
-
Várkonyi, Tamás
(author)
-
Reiners, Karlheinz
(author)
-
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Related titles
-
In:Journal of Clinical Medicine13:82077-0383
Internet link
Find in a library
To the university's database
- By the author/editor
-
Obeid, Rima
-
Andrès, Emmanuel
-
Češka, Richard
-
Hooshmand, Babak
-
Guéant-Rodriguez ...
-
Prada, Gabriel I ...
-
show more...
-
Sławek, Jarosław
-
Traykov, Latchez ...
-
Van, Binh Ta
-
Várkonyi, Tamás
-
Reiners, Karlhei ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Stockholm University
-
Karolinska Institutet