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NMR investigations ...
NMR investigations of interactions between anesthetics and lipid bilayers
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- Castro, Vasco (författare)
- Stockholms universitet,Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi
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- Stevensson, Baltzar (författare)
- Stockholms universitet,Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi
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- Dvinskikh, Sergey V. (författare)
- KTH,Fysikalisk kemi,Division of Physical Chemistry, Royal Institute of Technology, SE-10044 Stockholm, Sweden
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- Högberg, Carl-Johan (författare)
- Stockholms universitet,Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi
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- Lyubartsev, Alexander P. (författare)
- Stockholms universitet,Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi
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- Zimmermann, Herbert (författare)
- Department of Biophysics, Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany
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- Sandström, Dick (författare)
- Bruker BioSpin Scandinavia AB, Sweden
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- Maliniak, Arnold (författare)
- Stockholms universitet,Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2008
- 2008
- Engelska.
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Ingår i: Biochimica et Biophysica Acta - Biomembranes. - : ELSEVIER SCIENCE BV. - 0005-2736 .- 1879-2642. ; 1178:11, s. 2604-2611
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Interactions between anesthetics (lidocaine and short chain alcohols) and lipid membranes formed by dimyristoylphosphatidylcholine (DMPC) were studied using NMR spectroscopy. The orientational order of lidocaine was investigated using deuterium NMR on a selectively labelled compound whereas segmental ordering in the lipids was probed by two-dimensional 1H–13C separated local field experiments under magic-angle spinning conditions. In addition, trajectories generated in molecular dynamics (MD) computer simulations were used for interpretation of the experimental results. Separate simulations were carried out with charged and uncharged lidocaine molecules. Reasonable agreement between experimental dipolar interactions and the calculated counterparts was observed. Our results clearly show that charged lidocaine affects significantly the lipid headgroup. In particular the ordering of the lipids is increased accompanied by drastic changes in the orientation of the P–N vector in the choline group.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Solid-state NMR
- Carbon-13
- Phosphorus-31
- Deuterium
- Dipolar couplings
- Separated local field
- Quadrupolar coupling
- Order parameter
- Lyotropic liquid crystal
- Biomembrane
- Anesthetic
- Biophysical chemistry
- Biofysikalisk kemi
- Physical Chemistry
- fysikalisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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