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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
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- Herman, Maria Dolores (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Nyman, Tomas (author)
- Karolinska Institutet
- Welin, Martin (author)
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- Flodin, Susanne (author)
- Trésaugues, Lionel (author)
- Kotenyova, Tetyana (author)
- Flores, Alex (author)
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- (creator_code:org_t)
- 2008-09-21
- 2008
- English.
- In: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 582:25-26, s. 3590-3594
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Apoptosis
- B-cell lymphoma-2
- Cancer
- Bfl-1; A1
- Crystal structure
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Herman, Maria Do ...
- Nyman, Tomas
- Welin, Martin
- Lehtiö, Lari
- Flodin, Susanne
- Trésaugues, Lion ...
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- Kotenyova, Tetya ...
- Flores, Alex
- Nordlund, Pär
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- FEBS Letters
- By the university
- Stockholm University
- Karolinska Institutet
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