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  • Persson, MarieLinköpings universitet,Klinisk immunologi,Hälsouniversitetet (författare)

Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • Elsevier,2012
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-84900
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84900URI
  • https://doi.org/10.1016/j.jri.2012.05.003DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Swedish Research Council||Cancer and Allergy Association||Olle Engkvist Foundation||Vardal Foundation for Health Care Sciences and Allergy Research||National Swedish Association against Allergic Diseases||Linkoping University Hospital||
  • Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected longitudinally on three occasions during pregnancy and two occasions post partum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Twelve women fulfilled the criteria for allergy (allergic symptoms and circulating immunoglobulin [Ig] E antibodies to inhalant allergens) and 20 were non-allergic (nonsensitized without symptoms). The levels of Th1- and Th2-associated cytokines and chemokines, the Th17 cytokine IL-17 and the anti-inflammatory cytokine IL-10 of the groups were compared. Paternal antigen-induced IL-4 and IL-10 responses increased between the first and the third trimester. Allergy was associated with decreased paternal antigen-induced IFN-γ and CXCL10 secretion in the nonpregnant state (one year pp) and also decreased IFN-γ/IL-4 and IFN-γ/IL-13 ratios during pregnancy. We also observed a decreased paternal antigen-induced IL-10 response in allergic compared with non-allergic women during pregnancy, along with a decreased IL-10/IL-13 ratio. In conclusion, our findings support the hypothesis of lower Th1 responses toward paternal antigens in allergic than in non-allergic women, but also indicate that allergy is associated with a lower capacity to induce anti-inflammatory IL-10 responses after paternal antigen stimulation during pregnancy.

Ämnesord och genrebeteckningar

  • allergy
  • Th1/Th2
  • pregnancy
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ekerfelt, ChristinaLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)chrek55 (författare)
  • Ernerudh, JanÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (författare)
  • Matthiesen, LeifDepartment of Obstetrics and Gynecology, Helsingborg Hospital, Helsingborg, Sweden (författare)
  • Sandberg, MartinaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marsa92 (författare)
  • Jonsson, YvonneLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)yvojo35 (författare)
  • Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gorbe09 (författare)
  • Jenmalm, Maria C.Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18 (författare)
  • Linköpings universitetKlinisk immunologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Reproductive Immunology: Elsevier95:1-2, s. 50-580165-03781872-7603

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