Search: id:"swepub:oai:DiVA.org:su-29977" >
Common motifs and t...
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Hubner, Isaac A.
(author)
Common motifs and topological effects in the protein folding transition state.
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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Elsevier BV,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-29977
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29977URI
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https://doi.org/10.1016/j.jmb.2006.04.015DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Through extensive experiment, simulation, and analysis of protein S6 (IRIS), we find that variations in nucleation and folding pathway between circular permutations are determined principally by the restraints of topology and specific nucleation, and affected by changes in chain entropy. Simulations also relate topological features to experimentally measured stabilities. Despite many sizable changes in Φ values and the structure of the transition state ensemble that result from permutation, we observe a common theme: the critical nucleus in each of the mutants share a subset of residues that can be mapped to the critical nucleus residues of the wild-type. Circular permutations create new N and C termini, which are the location of the largest disruption of the folding nucleus, leading to a decrease in both Φ values and the role in nucleation. Mutant nuclei are built around the wild-type nucleus but are biased towards different parts of the S6 structure depending on the topological and entropic changes induced by the location of the new N and C termini.
Subject headings and genre
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ensemble
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simulatoin
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circular permutation
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protein S6
Added entries (persons, corporate bodies, meetings, titles ...)
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Lindberg, Magnus
(author)
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Haglund, Ellinor,1978-Stockholms universitet,Institutionen för biokemi och biofysik,Mikael Oliveberg(Swepub:su)ehagl
(author)
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Oliverberg, MikaelStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)moliv
(author)
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Shakhnovich, Eugene I.
(author)
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Stockholms universitetInstitutionen för biokemi och biofysik
(creator_code:org_t)
Related titles
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In:Journal of Molecular Biology: Elsevier BV359:4, s. 1075-10850022-28361089-8638
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