Sökning: WFRF:(Ström Kristoffer) >
Less pronounced res...
Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls
-
- Ekman, Carl (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Elgzyri, Targ (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Ström, Kristoffer (författare)
- Lund University,Lunds universitet,Mittuniversitetet,Avdelningen för hälsovetenskap,Swedish Winter Sports Research Center,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
visa fler...
-
- Almgren, Peter (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Parikh, Hemang (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden.;NCI, Lab Translat Gen, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
-
- Dekker Nitert, Marloes (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Department of Experimental Medical Science,Faculty of Medicine,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Rönn, Tina (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden.
-
- Koivula, Fiona (författare)
- Lund University,Lunds universitet,Människan i rörelse: hälsa och rehabilitering,Forskargrupper vid Lunds universitet,Human Movement: health and rehabilitation,Lund University Research Groups,Lund Univ, Div Physiotherapy, Dept Hlth Sci, Lund, Sweden,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Tornberg, Åsa (författare)
- Lund University,Lunds universitet,Människan i rörelse: hälsa och rehabilitering,Forskargrupper vid Lunds universitet,Human Movement: health and rehabilitation,Lund University Research Groups,Lund Univ, Div Physiotherapy, Dept Hlth Sci, Lund, Sweden.;Lund Univ, Genet Mol Epidemiol Unit, Ctr Diabet, Clin Res Ctr, Malmo, Sweden
-
- Wollmer, Per (författare)
- Lund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups,Lund Univ, Div Physiotherapy, Dept Hlth Sci, Lund, Sweden.;Lund Univ, Dept Clin Sci, Clin Physiol & Nucl Med Unit, Malmo, Sweden
-
- Eriksson, Karl-Fredrik (författare)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
-
- Groop, Leif (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
- Hansson, Ola (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2015
- 2015
- Engelska.
-
Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 119:9, s. 953-960
- Relaterad länk:
-
https://miun.diva-po... (primary) (Raw object)
-
visa fler...
-
https://europepmc.or...
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared with FH-. Sixteen FH+ and 19 FH- insulin-sensitive men similar in age, peak oxygen consumption ((V) over dot(O2 peak)), and body mass index completed an exercise intervention with heart rate monitored during exercise for 7 mo. Before and after the exercise intervention, the participants underwent a physical examination and tests for glucose tolerance and exercise capacity, and muscle biopsies were taken for expression analysis. The participants attended, on average, 39 training sessions during the intervention and spent 18.8 MJ on exercise. (V) over dot(O2 peak)/kg increased by 14%, and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH- group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on (V) over dot(O2 peak), weight, and waist circumference in the FH- group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation, and cellular respiration increased more in the FH- compared with the FH+ group. This suggests that healthy, insulin-sensitive FH+ and FH- participants with similar age, (V) over dot(O2 peak), and body mass index may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- type 2 diabetes
- exercise intervention
- expression analysis
- genetic predisposition
- muscle
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ekman, Carl
-
Elgzyri, Targ
-
Ström, Kristoffe ...
-
Almgren, Peter
-
Parikh, Hemang
-
Dekker Nitert, M ...
-
visa fler...
-
Rönn, Tina
-
Koivula, Fiona
-
Ling, Charlotte
-
Tornberg, Åsa
-
Wollmer, Per
-
Eriksson, Karl-F ...
-
Groop, Leif
-
Hansson, Ola
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Idrottsvetenskap
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Journal of appli ...
- Av lärosätet
-
Mittuniversitetet
-
Lunds universitet