Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations

• Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.

Subject headings

SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)

SOCIAL SCIENCES  -- Psychology (hsv//eng)

Keyword

multi-modal brain imaging

memory

striatal dopamine D2 binding

BOLD

Psychology

Psykologi

Psychology

psykologi

MEDICINE

Publication and Content Type

ref (subject category)

art (subject category)