Sökning: L773:1431 6730 OR L773:1437 4315 >
Antibacterial activ...
Antibacterial activity of radical scavengers against reductase from Bacillus anthracis
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Torrents, Eduard (författare)
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- Sjöberg, Britt-Marie (författare)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Biological chemistry (Print). - 1431-6730 .- 1437-4315. ; 391:2/3, s. 229-234
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bacillus anthracis is a severe mammalian pathogen. The deoxyribonucleotides necessary for DNA replication and repair are provided via the ribonucleotide reductase (RNR) enzyme. RNR is also important for spore germination and cell proliferation upon infection. We show that the expression of B. anthracis class Ib RNR responds to the environment that the pathogen encounters upon infection. We also show that several anti-proliferative agents (radical scavengers) specifically inhibit the B. anthracis RNR. Owing to the importance of RNR in the pathogenic infection process, our results highlight a promising potential to inhibit the growth of B. anthracis early during infection.
Nyckelord
- anthrax
- antibacterial drug
- antibacterial target
- enzyme inhibition
- NATURAL SCIENCES
- NATURVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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